Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation
文献类型：期刊论文
| 作者 | Xue LX(薛凌喜); He X(何萧); Li YY(李媛媛) ; 张智勇;Xue, LX; He, X; Li, YY; Qu, MH; Zhang, ZY
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2013 |
| 卷号 | 13期号:10页码:6575-6580 |
| 关键词 | Ceria Nanoparticles Pulmonary Toxicity Intratracheal Instillation |
| 英文摘要 | Ceria nanoparticles (nano-ceria) are widely used for various applications such as catalytic converters for automobile exhaust, ultraviolet absorber, and electrolyte in fuel cells. Their potential impacts on the environment and human health have also drawn people's attention. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after an acute intratracheal instillation. CD-1 mice were exposed to 0.04, 0.4, 4 and 40 mu g nano-ceria (corresponding to 10, 100, 1000 and 10000 times of the maximum exposure dose, respectively) and sacrificed at 1, 7, and 28 d post-exposure. Lung injury was assessed by bronchoalveolar ravage fluid (BALF) analysis, cell counts, biochemical analysis of lung homogenate, and histopathology. Cell differential analysis of the BALF show that the numbers of neutrophils and lymphocytes increased significantly in the mice exposed to 40 mu g nano-ceria at 1 d after instillation, and returned to control levels by 7 d. The lactate dehydrogenate activity in the BALF from the 40 mu g group increased significantly during the whole experimental period. Pathological changes were only found in the lung tissues from the mice of 40 mu g nano-ceria group. The changes were most obvious by 7 d post-exposure, and returned to normal by 28 d. No other changes were found. The results of the present study suggest that exposure to nano-ceria at the current levels in the ambient air may not cause respiratory toxicity. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000328704000014 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224281]  |
| 专题 | 高能物理研究所_粒子天体物理中心 |
| 推荐引用方式 GB/T 7714 | Xue LX,He X,Li YY,et al. Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(10):6575-6580. |
| APA | 薛凌喜.,何萧.,李媛媛.,张智勇；Xue, LX.,He, X.,...&Zhang, ZY.(2013).Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(10),6575-6580. |
| MLA | 薛凌喜,et al."Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.10(2013):6575-6580. |
入库方式： OAI收割
来源：高能物理研究所
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