Noise effects in nonlinear biochemical signaling
文献类型：期刊论文
| 作者 | Bostani, N; Kessler, DA; Shnerb, NM; Rappel, WJ; Levine, H |
| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2012 |
| 卷号 | 85期号:1页码:11901 |
| 英文摘要 | It has been generally recognized that stochasticity can play an important role in the information processing accomplished by reaction networks in biological cells. Most treatments of that stochasticity employ Gaussian noise even though it is a priori obvious that this approximation can violate physical constraints, such as the positivity of chemical concentrations. Here, we show that even when such nonphysical fluctuations are rare, an exact solution of the Gaussian model shows that the model can yield unphysical results. This is done in the context of a simple incoherent-feedforward model which exhibits perfect adaptation in the deterministic limit. We show how one can use the natural separation of time scales in this model to yield an approximate model, that is analytically solvable, including its dynamical response to an environmental change. Alternatively, one can employ a cutoff procedure to regularize the Gaussian result. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000299120300010 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224473]  |
| 专题 | 高能物理研究所_粒子天体物理中心 |
| 推荐引用方式 GB/T 7714 | Bostani, N,Kessler, DA,Shnerb, NM,et al. Noise effects in nonlinear biochemical signaling[J]. PHYSICAL REVIEW E,2012,85(1):11901. |
| APA | Bostani, N,Kessler, DA,Shnerb, NM,Rappel, WJ,&Levine, H.(2012).Noise effects in nonlinear biochemical signaling.PHYSICAL REVIEW E,85(1),11901. |
| MLA | Bostani, N,et al."Noise effects in nonlinear biochemical signaling".PHYSICAL REVIEW E 85.1(2012):11901. |
入库方式： OAI收割
来源：高能物理研究所
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