Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells
文献类型：期刊论文
| 作者 | Meng H(孟幻); Xing GM(邢更妹) ; Meng, H; Xing, GM; Blanco, E; Song, Y; Zhao, LN; Sun, BY; Li, XD; Wang, PC
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| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
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| 出版日期 | 2012 |
| 卷号 | 8期号:2页码:136-146 |
| 关键词 | Nanomedicine Metallofullerenol nanoparticles Cancer metastasis Matrix metalloproteinase Fibrous cage |
| 英文摘要 | The purpose of this work is to study the antimetastasis activity of gadolinium metallofullerenol nanoparticles (f-NPs) in malignant and invasive human breast cancer models. We demonstrated that f-NPs inhibited the production of matrix metalloproteinase (MMP) enzymes and further interfered with the invasiveness of cancer cells in tissue culture condition. In the tissue invasion animal model, the invasive primary tumor treated with f-NPs showed significantly less metastasis to the ectopic site along with the decreased MMP expression. In the same animal model, we observed the formation of a fibrous cage that may serve as a physical barrier capable of cancer tissue encapsulation that cuts the communication between cancer-and tumor-associated macrophages, which produce MMP enzymes. In another animal model, the blood transfer model, f-NPs potently suppressed the establishment of tumor foci in lung. Based on these data, we conclude that f-NPs have antimetastasis effects and speculate that utilization of f-NPs may provide a new strategy for the treatment of tumor metastasis. From the Clinical Editor: In this study utilizing metallofullerenol nanoparticles, the authors demonstrate antimetastasis effects and speculate that utilization of these nanoparticles may provide a new strategy in metastatic tumor therapy. (C) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Science & Technology - Other Topics; Research & Experimental Medicine |
| 收录类别 | SCI |
| WOS记录号 | WOS:000299316900002 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223861]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Meng H,Xing GM,Meng, H,et al. Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2012,8(2):136-146. |
| APA | 孟幻.,邢更妹.,Meng, H.,Xing, GM.,Blanco, E.,...&赵宇亮.(2012).Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,8(2),136-146. |
| MLA | 孟幻,et al."Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 8.2(2012):136-146. |
入库方式： OAI收割
来源：高能物理研究所
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