Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli
文献类型：期刊论文
| 作者 | He X(何潇) ; He, X; Li YY(李媛媛); Kuang, YS; Li, YY; Zhang, HF; Ma, YH; Bai, W; Zhang, ZY; Wu, ZQ
|
| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:3页码:233-240 |
| 关键词 | Ceria nanoparticles cytotoxicity exposure media surface charge density in situ assessment |
| 英文摘要 | Ceria nanoparticles have attracted a great deal of concern about their impact on human health and the environment due to their widespread applications. In the present work, different exposure media (normal saline and phosphate-buffered saline [PBS]) were used to adjust the surface charge density in order to investigate the influence of surface charge on the cytotoxicity of ceria nanoparticles for Escherichia coli. The results showed that the direct contact mediated by the electrostatic attraction between the cell wall and the positive-charged ceria nanoparticles in normal saline would result in outer membrane destabilization, increased reactive oxygen species (ROS) production and loss of viability. The situation in PBS was totally different, with significantly reduced contacts, so no outer membrane destabilization, no increased ROS production, and no cytotoxicity. The results suggested that surface charge density was closely involved in the cytotoxicity of ceria nanoparticles for E. coli. This work as a well designed comparison study contributes to a better understanding of the charge-associated biological effects of nanomaterials. |
| 学科主题 | Science & Technology - Other Topics; Toxicology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000302560400001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223901]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | He X,He, X,Li YY,et al. Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli[J]. NANOTOXICOLOGY,2012,6(3):233-240. |
| APA | 何潇.,He, X.,李媛媛.,Kuang, YS.,Li, YY.,...&柴之芳.(2012).Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli.NANOTOXICOLOGY,6(3),233-240. |
| MLA | 何潇,et al."Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli".NANOTOXICOLOGY 6.3(2012):233-240. |
入库方式： OAI收割
来源：高能物理研究所
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