The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease
文献类型：期刊论文
| 作者 | Wang HJ(王华建); Wang M(王萌) ; Wang B(汪冰); Wang, HJ; Wang, M; Wang, B; Li, M; Chen, HQ; Yu, XH; Zhao, YL
|
| 刊名 | METALLOMICS
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:3页码:289-296 |
| 英文摘要 | The enrichment of transition metals in the brain and the dyshomeostasis of metals are thought to be important etiological factors for elderly people in a number of neurodegenerative diseases, including Alzheimer's disease (AD). However, the understanding of how biometals dynamically dysregulate in the stages of AD development, such as the exact time-dependent and site-dependent accumulation in the brain with AD progression, is still limited. Herein, by using the APP/V717I transgenic mouse model and age-matched mice as control, we offer distinctive in situ and quantitative images of metals (Cu, Fe, Zn and Ca) in brain sections by synchrotron radiation micro beam X-ray fluorescence (SR-mu XRF). The images show that Fe and Ca increased with brain aging in both AD and control (CNT) mice, and Cu, Fe, Zn and Ca appeared significantly elevated in AD mice and showed an obvious age-dependent rise. Fe, Cu and Zn were obviously specifically enriched in the cortex and hippocampus, which were also the plaque-formation sensitive brain regions. Our results demonstrate that the enrichment of transition metals with age and metals' dyshomeostasis in specific regions may contribute together to the etiology and development of AD in elderly people. The XANES measurements of Cu and Fe show evidence that Cu may have redox properties in the AD brain. |
| 学科主题 | Biochemistry & Molecular Biology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000300886700008 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223928]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_粒子天体物理中心 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Wang HJ,Wang M,Wang B,et al. The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease[J]. METALLOMICS,2012,4(3):289-296. |
| APA | 王华建.,王萌.,汪冰.,Wang, HJ.,Wang, M.,...&柴之芳.(2012).The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease.METALLOMICS,4(3),289-296. |
| MLA | 王华建,et al."The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease".METALLOMICS 4.3(2012):289-296. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。