Cu-64 Radiopharmaceutical Chemistry
文献类型：期刊论文
| 作者 | Ma L(马磊); 刘宇(多); Chai ZF(柴之芳); Ma, L; Liu, Y; Chai, ZF |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 24期号:9页码:1720-1728 |
| 关键词 | radiopharmaceutical Cu-64 ligands |
| 英文摘要 | Copper-64, as a radionuclide, can be simultaneously used for both imaging and potential therapy, because of its specific nuclear characteristics, such as the half-life (12. 7 h) and decay properties (beta(+), 0. 653 MeV, 17. 8%; beta(-), 0. 579 MeV, 38. 4%). In the past two decades, with the well-established copper coordination chemistry, more and more novel ligands for copper-64 have been designed and synthesized, like DOTA, TETA, NOTA, CB-TE2A, C3B-DO2A, etc. Nowadays, copper-64 is able to bind not only with biologically relevant small molecules, but also with some antibodies, proteins, and nanoparticles. From another point of view, the stability of the copper-64-labeled radiopharmaceuticals has been significantly improved in both vitro and vivo tests. Thus, the exploration of novel ligands and receptors with new labeling strategies has become a hot issue in the copper radiopharmaceutical chemistry. Up to now, many new copper-64-labeled radiopharmaceuticals have been synthesized, some of which exhibit excellent biodistributions, as Cu-64-ATSM is an effective radiopharmaceutical in imaging of hypoxic tissues and Cu-64-PTSM is a good blood flow tracer, etc. This paper will selectively review some new labeling methods for copper-64-labeled radiopharmaceuticals, and some potential applications of these coordination compounds in both imaging and therapy. The perspectives of this field is addressed as well. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000309485800010 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224165]  |
| 专题 | 高能物理研究所_院士 |
| 推荐引用方式 GB/T 7714 | Ma L,Liu Y,Chai ZF,et al. Cu-64 Radiopharmaceutical Chemistry[J]. PROGRESS IN CHEMISTRY,2012,24(9):1720-1728. |
| APA | 马磊,刘宇,柴之芳,Ma, L,Liu, Y,&Chai, ZF.(2012).Cu-64 Radiopharmaceutical Chemistry.PROGRESS IN CHEMISTRY,24(9),1720-1728. |
| MLA | 马磊,et al."Cu-64 Radiopharmaceutical Chemistry".PROGRESS IN CHEMISTRY 24.9(2012):1720-1728. |
入库方式： OAI收割
来源：高能物理研究所
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