Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations
文献类型：期刊论文
| 作者 | Zhang HF(张海峰); He X(何潇) ; Zhang ZY(张智勇); Zhang, HF; He, XA; Zhang, ZY; Zhang, P; Li, YY; Ma, YH; Kuang, YS
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2011 |
| 卷号 | 45期号:8页码:3725-3730 |
| 英文摘要 | Ceria nanoparticles (nano-CeO2), due to their widespread applications, have attracted a lot of concern about their toxic effects on both human health and the environment. The present work aimed to evaluate the in vivo effects of nano-CeO2 (8.5 nm) on Caenorhabditis elegans (C. elegans) at environmental relevant concentrations (molar concentrations ranging from 1 nM to 100 nM). The results indicate that nano-CeO2 could induce ROS accumulation and oxidative damage in C. elegans, and finally lead to a decreased lifespan. The most surprising thing is that the mean lifespan of nematodes was significantly decreased by 12% even at the exposure level of 1 nM (p < 0.01). In vitro tests suggest that the ability of nano-CeO2 to catalyze ROS generation was involved in the mechanism for its toxicity to C. elegans. To our best knowledge, this is the first case in which nanoparticles exhibit adverse effects on organisms at such low concentrations (1 nM-100 nM). So, our findings indicate the importance of nanotoxicological investigations at: environmentally relevant concentrations and will attract more attentions on the risks of NPs exposure. |
| 学科主题 | Engineering; Environmental Sciences & Ecology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000289341300075 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224241]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zhang HF,He X,Zhang ZY,et al. Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2011,45(8):3725-3730. |
| APA | 张海峰.,何潇.,张智勇.,Zhang, HF.,He, XA.,...&柴之芳.(2011).Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations.ENVIRONMENTAL SCIENCE & TECHNOLOGY,45(8),3725-3730. |
| MLA | 张海峰,et al."Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations".ENVIRONMENTAL SCIENCE & TECHNOLOGY 45.8(2011):3725-3730. |
入库方式： OAI收割
来源：高能物理研究所
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