Toxicity of inorganic nanomaterials in biomedical imaging
文献类型：期刊论文
| 作者 | Li JX(李金霞) ; Chang XL(常雪灵); Li, JX; Chang, XL; Chen, XX; Gu, ZJ; Zhao, F; Chai, ZF; Zhao, YL; Gu ZJ(谷战军)
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| 刊名 | BIOTECHNOLOGY ADVANCES
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| 出版日期 | 2014 |
| 卷号 | 32期号:SI4页码:727-743 |
| 关键词 | Medical imaging Inorganic materials Nanomedicine Nanotoxicity Iron nanoparticles QDs Gold nanoparticles Upconversion nanoparticles |
| 英文摘要 | Inorganic nanoparticles have shown promising potentials as novel biomedical imaging agents with high sensitivity, high spatial and temporal resolution. To translate the laboratory innovations into clinical applications, their potential toxicities are highly concerned and have to be evaluated comprehensively both in vitro and in vivo before their clinical applications. In this review, we first summarized the in vivo and in vitro toxicities of the representative inorganic nanoparticles used in biomedical imagings. Then we further discuss the origin of nanotoxicity of inorganic nanomaterials, including ROS generation and oxidative stress, chemical instability, chemical composition, the surface modification, dissolution of nanoparticles to release excess free ions of metals, metal redox state, and left-over chemicals from synthesis, etc. We intend to provide the readers a better understanding of the toxicology aspects of inorganic nanomaterials and knowledge for achieving optimized designs of safer inorganic nanomaterials for clinical applications. (C) 2014 Elsevier Inc. All rights reserved. |
| 学科主题 | Biotechnology & Applied Microbiology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000338818300006 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224866]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Li JX,Chang XL,Li, JX,et al. Toxicity of inorganic nanomaterials in biomedical imaging[J]. BIOTECHNOLOGY ADVANCES,2014,32(SI4):727-743. |
| APA | 李金霞.,常雪灵.,Li, JX.,Chang, XL.,Chen, XX.,...&赵宇亮.(2014).Toxicity of inorganic nanomaterials in biomedical imaging.BIOTECHNOLOGY ADVANCES,32(SI4),727-743. |
| MLA | 李金霞,et al."Toxicity of inorganic nanomaterials in biomedical imaging".BIOTECHNOLOGY ADVANCES 32.SI4(2014):727-743. |
入库方式： OAI收割
来源：高能物理研究所
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