Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
文献类型：期刊论文
| 作者 | Peng, L; He X(何潇) ; 张鹏(多); He, X; Zhang, P; Zhang, J; Li, YY; Zhang, JZ; Ma, YH; Ding, YY
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2014 |
| 卷号 | 15期号:4页码:6072-6085 |
| 关键词 | nano-ceria pulmonary toxicity agglomerates size distribution surface chemistry |
| 英文摘要 | Ceria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after a single exposure via intratracheal instillation. Two types of nano-ceria with the same distribution of a primary size (3-5 nm), but different redox activity, were used: Ceria-p, synthesized by a precipitation route, and Ceria-h, synthesized by a hydrothermal route. Both Ceria-p and Ceria-h induced oxidative stress, inflammatory responses and cytotoxicity in mice, but their toxicological profiles were quite different. The mean size of Ceria-p agglomerates was much smaller compared to Ceria-h, thereby causing a more potent acute inflammation, due to their higher number concentration of agglomerates and higher deposition rate in the deep lung. Ceria-h had a higher reactivity to catalyzing the generation of reactive oxygen species (ROS), and caused two waves of lung injury: bronchoalveolar lavage (BAL) inflammation and cytotoxicity in the early stage and redox-activity-evoked lipid peroxidation and pro-inflammation in the latter stage. Therefore, the size distribution of ceria-containing agglomerates in the exhaust, as well as their surface chemistry are essential characteristics to assess the potential risks of using nano-ceria as a fuel additive. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000336841200060 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225047]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Peng, L,He X,Zhang P,et al. Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(4):6072-6085. |
| APA | Peng, L.,何潇.,张鹏.,He, X.,Zhang, P.,...&张静.(2014).Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,15(4),6072-6085. |
| MLA | Peng, L,et al."Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15.4(2014):6072-6085. |
入库方式： OAI收割
来源：高能物理研究所
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