Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats
文献类型：期刊论文
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| 作者 | Zhu MT(朱墨桃); Feng WY(丰伟悦) ; Wang B(汪冰); Wang M(王萌); Wang M(王萌); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Zhu, MT; Feng, WY
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| 刊名 | TOXICOLOGY
 ; TOXICOLOGY
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| 出版日期 | 2008 ; 2008 |
| 卷号 | 247期号:2-3页码:#REF! |
| 关键词 | ferric oxide nanoparticle pulmonary response coagulatory disturbance intratracheal instillation ferric oxide nanoparticle pulmonary response coagulatory disturbance intratracheal instillation |
| DOI | 10.1016/j.tox.2008.02.011 |
| 通讯作者 | Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Efffects Nanomat & Nanosafety, Beijing 100049, Peoples R China. ; Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Efffects Nanomat & Nanosafety, Beijing 100049, Peoples R China. |
| 文献子类 | Article |
| 英文摘要 | Ferric oxide (Fe(2)O(3)) nanoparticles are of considerable interest for application in nanotechnology related fields. However, as iron being a highly redox-active transition metal, the safety of iron nanomaterials need to be further studied. In this study, the size, dose and time dependent of Fe(2)O(3) nanoparticle on pulmonary and coagulation system have been studied after intratracheal instillation. The Fe(2)O(3) nanoparticles with mean diameters of 22 and 280 nm, respectively, were intratracheally instilled to male Sprague Dawley rats at low (0.8 mg/kg bw) and high (20 mg/kg bw) doses. The toxic effects were monitored in the post-instilled 1, 7 and 30 days. Our results showed that the Fe(2)O(3) nanoparticle exposure could induce oxidative stress in lung. Alveolar macrophage (AM) over-loading of phagocytosed nanoparticle by high dose treatment had occurred, while the non-phagocytosed particles were found entering into alveolar epithelial in day 1 after exposure. Several inflammatory reactions including inflammatory and immune cells increase, clinical pathological changes: follicular hyperplasia, protein effusion, pulmonary capillary vessel hyperaemia and alveolar lipoproteinosis in lung were observed. The sustain burden of particles in AM and epithelium cells has caused lung emphysema and pro-sign of lung fibrosis. At the post-instilled day 30, the typical coagulation parameters, prothrombin time (PT) and activated partial thromboplastin time (APTT) in blood of low dose 22 nm-Fe(2)O(3) treated rats were significantly longer than the controls. We concluded that both of the two-sized Fe(2)O(3) particle intratracheal exposure could induce lung injury. Comparing with the submicron-sized Fe(2)O(3) particle, the nano-sized Fe(2)O(3) particle may increase microvascular permeability and cell lysis in lung epitheliums and disturb blood coagulation parameters significantly. (C) 2008 Elsevier Ireland Ltd. All rights reserved.; Ferric oxide (Fe(2)O(3)) nanoparticles are of considerable interest for application in nanotechnology related fields. However, as iron being a highly redox-active transition metal, the safety of iron nanomaterials need to be further studied. In this study, the size, dose and time dependent of Fe(2)O(3) nanoparticle on pulmonary and coagulation system have been studied after intratracheal instillation. The Fe(2)O(3) nanoparticles with mean diameters of 22 and 280 nm, respectively, were intratracheally instilled to male Sprague Dawley rats at low (0.8 mg/kg bw) and high (20 mg/kg bw) doses. The toxic effects were monitored in the post-instilled 1, 7 and 30 days. Our results showed that the Fe(2)O(3) nanoparticle exposure could induce oxidative stress in lung. Alveolar macrophage (AM) over-loading of phagocytosed nanoparticle by high dose treatment had occurred, while the non-phagocytosed particles were found entering into alveolar epithelial in day 1 after exposure. Several inflammatory reactions including inflammatory and immune cells increase, clinical pathological changes: follicular hyperplasia, protein effusion, pulmonary capillary vessel hyperaemia and alveolar lipoproteinosis in lung were observed. The sustain burden of particles in AM and epithelium cells has caused lung emphysema and pro-sign of lung fibrosis. At the post-instilled day 30, the typical coagulation parameters, prothrombin time (PT) and activated partial thromboplastin time (APTT) in blood of low dose 22 nm-Fe(2)O(3) treated rats were significantly longer than the controls. We concluded that both of the two-sized Fe(2)O(3) particle intratracheal exposure could induce lung injury. Comparing with the submicron-sized Fe(2)O(3) particle, the nano-sized Fe(2)O(3) particle may increase microvascular permeability and cell lysis in lung epitheliums and disturb blood coagulation parameters significantly. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Toxicology ; Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000256208400005 ; WOS:000256208400005 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226159]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zhu MT,Feng WY,Wang B,et al. Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats, Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats[J]. TOXICOLOGY, TOXICOLOGY,2008, 2008,247, 247(2-3):#REF!, #REF!. |
| APA | 朱墨桃.,丰伟悦.,汪冰.,王萌.,王萌.,...&Chai, ZF.(2008).Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats.TOXICOLOGY,247(2-3),#REF!. |
| MLA | 朱墨桃,et al."Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats".TOXICOLOGY 247.2-3(2008):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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