Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver
文献类型：期刊论文
| 作者 | Chen CY(陈春英); Zhang PQ(章佩群); Chai ZF(柴之芳) ; Chen, CY; Zhang, PQ; Chai, ZF
|
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2005 |
| 卷号 | 50期号:2页码:#REF! |
| 关键词 | human liver subcellular fraction distribution heavy metals methylmercury |
| 通讯作者 | Chen, CY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100039, Peoples R China. |
| 英文摘要 | Liver, as an important metabolic and detoxicological organ of human body, can be used as a good bioindicator for evaluating body burden of environmental pollutants. Its elemental contents and their chemical forms are closely related to the status of human health and disease. In this paper, the liver samples collected from normal subjects were separated to different subcellular fractions of nuclei, mitochondria, lysosome, microsome and cytosol by differential centrifugation. Then their concentrations of heavy metals of As, Pb, Cd, and Hg were determined by atomic absorption and atomic fluorescent spectroscopy. Our results show no significant difference with literature ones when comparing their gross concentrations. In the case of their subcellular distribution, the Hg concentrations are higher in mitochondrial, microsomal and cytosolic fractions; the Cd concentrations are higher in cytosolic and mitochondrial fractions, while As highest in nuclear fraction. The highest concentration of Pb is found in microsomal fraction with similarity to Fe. Mercury in liver is mainly in the form of inorganic, and methylmercury ranged from 9% to 50% with the average value of 20.9% +/- 13.3%. These results indicate that the cellular distribution and the accumulated target organelles are quite different among these heavy metals, which suggest their various pathways and toxic mechanism in vivo. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 收录类别 | SCI |
| WOS记录号 | WOS:000228262700004 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226250]  |
| 专题 | 高能物理研究所_院士 |
| 推荐引用方式 GB/T 7714 | Chen CY,Zhang PQ,Chai ZF,et al. Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver[J]. CHINESE SCIENCE BULLETIN,2005,50(2):#REF!. |
| APA | 陈春英,章佩群,柴之芳,Chen, CY,Zhang, PQ,&Chai, ZF.(2005).Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver.CHINESE SCIENCE BULLETIN,50(2),#REF!. |
| MLA | 陈春英,et al."Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver".CHINESE SCIENCE BULLETIN 50.2(2005):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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