Long-term effects of lanthanum intake on the neurobehavioral development of the rat
文献类型：期刊论文
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| 作者 | Feng LX(冯流星); He X(何潇) ; Xiao HQ(肖海清); Li ZJ(李子杰); Li FL(李福亮); Liu NQ(刘年庆); Chai ZF(柴之芳); Zhao YL(赵宇亮); Zhang ZY(张智勇); Feng, LX
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| 刊名 | NEUROTOXICOLOGY AND TERATOLOGY
 ; NEUROTOXICOLOGY AND TERATOLOGY
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| 出版日期 | 2006 ; 2006 |
| 卷号 | 28期号:1页码:#REF! |
| 关键词 | lanthanum neurobehavioral development central nervous system lanthanum neurobehavioral development central nervous system |
| DOI | 10.1016/j.ntt.2005.10.007 |
| 通讯作者 | Zhang, ZY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Techn, Beijing 100049, Peoples R China. ; Zhang, ZY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Techn, Beijing 100049, Peoples R China. |
| 文献子类 | Article |
| 英文摘要 | The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameters and neurobehaviors were assessed, including body weight gain, pinna detachment, eye opening, surface righting reflex and swimming endurance. At 30 days of age, DNA concentration and protein/DNA ratio of the whole brain were determined. At 150 days of age, the Morris water maze test was carried out to study the memory and learning abilities of the rats. Differences were found in the body weight gain, surface righting reflex and swimming endurance. Moreover, lanthanum exposure significantly altered the DNA concentration and Protein/DNA in brain. The Morris water maze test showed that lanthanum exposure at 40 mg/kg significantly impaired memory and learning abilities. These findings indicate that lanthanum is a potential behavior teratogen. The information provided by this work should be considered in future applications of lanthanides. (c) 2005 Elsevier Inc. All rights reserved.; The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameters and neurobehaviors were assessed, including body weight gain, pinna detachment, eye opening, surface righting reflex and swimming endurance. At 30 days of age, DNA concentration and protein/DNA ratio of the whole brain were determined. At 150 days of age, the Morris water maze test was carried out to study the memory and learning abilities of the rats. Differences were found in the body weight gain, surface righting reflex and swimming endurance. Moreover, lanthanum exposure significantly altered the DNA concentration and Protein/DNA in brain. The Morris water maze test showed that lanthanum exposure at 40 mg/kg significantly impaired memory and learning abilities. These findings indicate that lanthanum is a potential behavior teratogen. The information provided by this work should be considered in future applications of lanthanides. (c) 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Neurosciences & Neurology; Toxicology ; Neurosciences & Neurology; Toxicology |
| 类目[WOS] | Neurosciences ; Toxicology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000236069500012 ; WOS:000236069500012 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226282]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Feng LX,He X,Xiao HQ,et al. Long-term effects of lanthanum intake on the neurobehavioral development of the rat, Long-term effects of lanthanum intake on the neurobehavioral development of the rat[J]. NEUROTOXICOLOGY AND TERATOLOGY, NEUROTOXICOLOGY AND TERATOLOGY,2006, 2006,28, 28(1):#REF!, #REF!. |
| APA | 冯流星.,何潇.,肖海清.,李子杰.,李福亮.,...&Zhang, ZY.(2006).Long-term effects of lanthanum intake on the neurobehavioral development of the rat.NEUROTOXICOLOGY AND TERATOLOGY,28(1),#REF!. |
| MLA | 冯流星,et al."Long-term effects of lanthanum intake on the neurobehavioral development of the rat".NEUROTOXICOLOGY AND TERATOLOGY 28.1(2006):#REF!. |
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来源：高能物理研究所
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