Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique
文献类型：期刊论文
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| 作者 | Feng WY(丰伟悦) ; Ding WJ(丁万见); Qian QF(钱琴芳); Chai ZF(柴之芳); Feng, WY; Ding, WJ; Qian, GF; Chai, ZF
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| 刊名 | BIOLOGICAL TRACE ELEMENT RESEARCH
 ; BIOLOGICAL TRACE ELEMENT RESEARCH
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| 出版日期 | 1999 ; 1999 |
| 卷号 | 25965页码:#REF! |
| 关键词 | Enriched stable isotope Cr-50(III) subcellular distribution diabetes INAA Enriched stable isotope Cr-50(III) subcellular distribution diabetes INAA |
| DOI | 10.1007/BF02784198 |
| 通讯作者 | Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China. ; Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China. |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | The enriched stable isotope Cr-50(III) tracer technique combined with neutron activation analysis was used to examine the intracellular distribution of Cr(III) in the liver, pancreas, testes, and kidney homogenates of both normal and diabetic rats. Our new results showed that the nucleic fraction has the highest Cr concentration in the Liver cell of both normal and diabetic rats. The diabetic rats retain more Cr in the mitochondrial and lysosomal fractions of liver homogenate than the normal. This is likely an indication of chromium participating in the glucose or lipid metabolism to compensate the low level of insulin in the body of diabetic rats. The concentrations of Cr in the subcellular fractions of pancreas, testes, and kidney in the normal rats are higher than those in the diabetic rats, which favor the hypothesis that Cr(LII) plays its biological function via interaction with the insulin-sensitive tissues or enhancement of the sensitivity of the insulin receptor.; The enriched stable isotope Cr-50(III) tracer technique combined with neutron activation analysis was used to examine the intracellular distribution of Cr(III) in the liver, pancreas, testes, and kidney homogenates of both normal and diabetic rats. Our new results showed that the nucleic fraction has the highest Cr concentration in the Liver cell of both normal and diabetic rats. The diabetic rats retain more Cr in the mitochondrial and lysosomal fractions of liver homogenate than the normal. This is likely an indication of chromium participating in the glucose or lipid metabolism to compensate the low level of insulin in the body of diabetic rats. The concentrations of Cr in the subcellular fractions of pancreas, testes, and kidney in the normal rats are higher than those in the diabetic rats, which favor the hypothesis that Cr(LII) plays its biological function via interaction with the insulin-sensitive tissues or enhancement of the sensitivity of the insulin receptor. |
| 学科主题 | Biochemistry & Molecular Biology; Endocrinology & Metabolism ; Biochemistry & Molecular Biology; Endocrinology & Metabolism |
| 类目[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 收录类别 | SCI |
| WOS记录号 | WOS:000084610100015 ; WOS:000084610100015 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226300]  |
| 专题 | 高能物理研究所_院士 |
| 推荐引用方式 GB/T 7714 | Feng WY,Ding WJ,Qian QF,et al. Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique, Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique[J]. BIOLOGICAL TRACE ELEMENT RESEARCH, BIOLOGICAL TRACE ELEMENT RESEARCH,1999, 1999,25965, 25965:#REF!, #REF!. |
| APA | 丰伟悦.,丁万见.,钱琴芳.,柴之芳.,Feng, WY.,...&Chai, ZF.(1999).Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique.BIOLOGICAL TRACE ELEMENT RESEARCH,25965,#REF!. |
| MLA | 丰伟悦,et al."Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique".BIOLOGICAL TRACE ELEMENT RESEARCH 25965(1999):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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