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Investigation of selenium distribution in subcellular fractions of human liver by neutron activation analysis

文献类型：期刊论文

;
作者Chen CY(陈春英); Zhang PQ(章佩群); Hou XL(侯小琳); Chai ZF(柴之芳); Chen, CY; Zhang, PQ; Hou, XL; Chai, ZF
刊名BIOLOGICAL TRACE ELEMENT RESEARCH ; BIOLOGICAL TRACE ELEMENT RESEARCH
出版日期1999 ; 1999
卷号25965页码:#REF!
关键词selenium subcellular distribution human liver neutron activation analysis selenium subcellular distribution human liver neutron activation analysis
DOI10.1007/BF02784199
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China. ; Chen, CY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China.
文献子类Article; Proceedings Paper
英文摘要Selenium is an important and essential trace element to living systems. In the article, two methods of instrumental neutron activation analysis and hydride generation-atomic fluorescence spectrometry were applied to determine Se in biological samples and the accuracy was evaluated by several reference materials. The subcellular distribution of selenium in human liver samples, which were obtained from normal subjects who had an accidental death, was investigated by differential centrifugation combined with INAA. Selenium was mainly enriched in mitochondria, nuclei, and cytosol. Almost half of the total Se content existed in nuclei as a result of the large amount in liver and the high Se concentration. Generally, the highest Se concentration in the mitochondrial fractions of each liver sample suggested that Se had important functions in this Liver component.; Selenium is an important and essential trace element to living systems. In the article, two methods of instrumental neutron activation analysis and hydride generation-atomic fluorescence spectrometry were applied to determine Se in biological samples and the accuracy was evaluated by several reference materials. The subcellular distribution of selenium in human liver samples, which were obtained from normal subjects who had an accidental death, was investigated by differential centrifugation combined with INAA. Selenium was mainly enriched in mitochondria, nuclei, and cytosol. Almost half of the total Se content existed in nuclei as a result of the large amount in liver and the high Se concentration. Generally, the highest Se concentration in the mitochondrial fractions of each liver sample suggested that Se had important functions in this Liver component.
学科主题Biochemistry & Molecular Biology; Endocrinology & Metabolism ; Biochemistry & Molecular Biology; Endocrinology & Metabolism
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
收录类别SCI
WOS记录号WOS:000084610100016 ; WOS:000084610100016
公开日期2016-05-03
源URL[http://ir.ihep.ac.cn/handle/311005/226389]  
专题高能物理研究所_院士
推荐引用方式
GB/T 7714		 Chen CY,Zhang PQ,Hou XL,et al. Investigation of selenium distribution in subcellular fractions of human liver by neutron activation analysis, Investigation of selenium distribution in subcellular fractions of human liver by neutron activation analysis[J]. BIOLOGICAL TRACE ELEMENT RESEARCH, BIOLOGICAL TRACE ELEMENT RESEARCH,1999, 1999,25965, 25965:#REF!, #REF!.
APA 陈春英.,章佩群.,侯小琳.,柴之芳.,Chen, CY.,...&Chai, ZF.(1999).Investigation of selenium distribution in subcellular fractions of human liver by neutron activation analysis.BIOLOGICAL TRACE ELEMENT RESEARCH,25965,#REF!.
MLA 陈春英,et al."Investigation of selenium distribution in subcellular fractions of human liver by neutron activation analysis".BIOLOGICAL TRACE ELEMENT RESEARCH 25965(1999):#REF!.

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来源：高能物理研究所

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