Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity
文献类型：期刊论文
| 作者 | Wang, XC; Hu, ZH; Fang, ZY; Feng, Y; Yang, YH; Wang, Q; Tang, XW; Wu, YG; Wang, JZ; Tang XW(唐孝威)
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| 刊名 | CURRENT ALZHEIMER RESEARCH
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| 出版日期 | 2004 |
| 卷号 | 1期号:2页码:#REF! |
| 关键词 | Alzheimer's disease tau hyperphosphorylation Isoproterenol fMRI BOLD signal CMRO(2) CBF |
| 通讯作者 | Wang, JZ (reprint author), Huazhong Univ Sci & Technol, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China. |
| 英文摘要 | To explore the correlation between cerebral functional alterations revealed by functional magnetic resonance imaging (fMRI) and Alzheimer disease- (AD)-like tau hyperphosphorylation, we injected bilaterally 2 mu l each of 20 mM isoproterenol (IP), a PKA activator, or of saline as a vehicle control into the hippocampus of rats. FMRI was employed to measure the intensity of BOLD signal, one of the cerebral functional markers reflecting the changes of cerebral metabolic rate of oxygen (CMRO(2)) and cerebral blood flow (CBF), in hippocampus and cortex 24 h after the operation. Immunohistochemical staining of hippocampus and cortex was carried out using phosphorylation-dependent tau antibodies. The results showed (1) that BOLD intensity in hippocampus and cortex of IP-injected rats was obviously lower than that of sham-operated group, indicating a decrease in CMRO(2) and CBF of the particular brain regions in IP-treated rats; (2) that tau was hyperphosphorylated at Ser-262/Ser-356 (12e8), Ser-396/Ser-404 (PHF-1) sites in CA1 CA2 CA3 CA4 and dentate gyrus regions of hippocampal formation and cortex area in IP group, but not in sham rats; (3) that a negative correlation between tau hyperphosphorylation and BOLD intensity in hippocampus and cortex area of IP rats was observed. The data suggested that hippocampal and cortical tau hyperphosphorylation was intimately related to BOLD intensity of the same areas. To our knowledge, this is the first report exploring the relationship between fMRI BOLD signal and AD-like tau hyperphosphorylation. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Clinical Neurology ; Neurosciences |
| 收录类别 | SCI |
| WOS记录号 | WOS:000207883500010 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226480]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_粒子天体物理中心 |
| 推荐引用方式 GB/T 7714 | Wang, XC,Hu, ZH,Fang, ZY,et al. Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity[J]. CURRENT ALZHEIMER RESEARCH,2004,1(2):#REF!. |
| APA | Wang, XC.,Hu, ZH.,Fang, ZY.,Feng, Y.,Yang, YH.,...&吴义根.(2004).Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity.CURRENT ALZHEIMER RESEARCH,1(2),#REF!. |
| MLA | Wang, XC,et al."Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity".CURRENT ALZHEIMER RESEARCH 1.2(2004):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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