中国科学院机构知识库网格系统: The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure

The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure

文献类型：期刊论文

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作者	Chen CY(陈春英); Yu HW(喻宏伟); Zhao JJ(赵九江); Li B(李柏); Zhang PQ(章佩群); Chai ZF(柴之芳); Chen, CY; Yu, HW; Zhao, JJ; Li, B
刊名	ENVIRONMENTAL HEALTH PERSPECTIVES ; ENVIRONMENTAL HEALTH PERSPECTIVES
出版日期	2006 ; 2006
卷号	114 期号:2 页码:#REF!
关键词	antagonism Hg-exposed subjects mercury selenium selenoproteins serum antagonism Hg-exposed subjects mercury selenium selenoproteins serum
DOI	10.1289/ehp.7861
通讯作者	Chen, CY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China. ; Chen, CY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China.
文献子类	Article; Proceedings Paper
英文摘要	Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to elucidate the possible roles of serum Se and selenoproteins in transporting and binding Hg in human populations. We collected data from 72 subjects: 35 had very low Hg exposure as evidenced by mean Hg concentrations of 0.91 and 1.25 ng/mL measured in serum and urine, respectively; 37 had high exposure (mean Hg concentrations of 38.5 and 86.8 ng/mL measured in serum and urine, respectively). An association between Se and Hg was found in urine (r = 0.625; p < 0.001) but not in serum. Hg exposure may affect Se concentrations and selenoprotein distribution in human serum. Expression of both selenoprotein P and glutathione peroxidase (GSH-Px) was greatly increased in Hg miners. These increases were accompanied by elevated Se concentrations in serum. In addition, selenoprotein P bound more Hg at higher Hg exposure concentrations. Biochemical observations revealed that both GSH-Px activity and malondialdehyde concentrations increased in serum of the Hg-exposed group. This study aids in the understanding of the interaction between Se and Hg. Selenoproteins play two important roles in protecting against Hg toxicity. First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo.; Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to elucidate the possible roles of serum Se and selenoproteins in transporting and binding Hg in human populations. We collected data from 72 subjects: 35 had very low Hg exposure as evidenced by mean Hg concentrations of 0.91 and 1.25 ng/mL measured in serum and urine, respectively; 37 had high exposure (mean Hg concentrations of 38.5 and 86.8 ng/mL measured in serum and urine, respectively). An association between Se and Hg was found in urine (r = 0.625; p < 0.001) but not in serum. Hg exposure may affect Se concentrations and selenoprotein distribution in human serum. Expression of both selenoprotein P and glutathione peroxidase (GSH-Px) was greatly increased in Hg miners. These increases were accompanied by elevated Se concentrations in serum. In addition, selenoprotein P bound more Hg at higher Hg exposure concentrations. Biochemical observations revealed that both GSH-Px activity and malondialdehyde concentrations increased in serum of the Hg-exposed group. This study aids in the understanding of the interaction between Se and Hg. Selenoproteins play two important roles in protecting against Hg toxicity. First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo.
学科主题	Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology ; Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology
类目[WOS]	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
收录类别	SCI
WOS记录号	WOS:000235226300054 ; WOS:000235226300054
公开日期	2016-05-03
源URL	[http://ir.ihep.ac.cn/handle/311005/227488]
专题	高能物理研究所_院士高能物理研究所_实验物理中心
推荐引用方式 GB/T 7714	Chen CY,Yu HW,Zhao JJ,et al. The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure, The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, ENVIRONMENTAL HEALTH PERSPECTIVES,2006, 2006,114, 114(2):#REF!, #REF!.
APA	陈春英.,喻宏伟.,赵九江.,李柏.,章佩群.,...&Chai, ZF.(2006).The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure.ENVIRONMENTAL HEALTH PERSPECTIVES,114(2),#REF!.
MLA	陈春英,et al."The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure".ENVIRONMENTAL HEALTH PERSPECTIVES 114.2(2006):#REF!.

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来源：高能物理研究所

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