Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry
文献类型：期刊论文
| 作者 | Zheng LN(郑令娜) ; Wang M(王萌); Zhao LC(赵磊超); Sun BY(孙宝云); Wang B(汪冰); Chen HQ(陈汉清); Zhao YL(赵宇亮); Chai ZF(柴之芳); 丰伟悦Zheng, LN; Wang, M
|
| 刊名 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 407期号:9页码:2383-2391 |
| 关键词 | Cisplatin Gd@C-82(OH)(22) Single cell ICP-MS Quantitative analysis |
| 通讯作者 | 丰伟悦 |
| 英文摘要 | Cisplatin is a commonly used chemotherapeutic drug in cancer treatment, whereas Gd@C-82(OH)(22) is a new nanomaterial anti-tumor agent. In this study, we determined intracellular Gd@C-82(OH)(22) and cisplatin after treatment of Hela and 16HBE cells by single cell inductively coupled plasma-mass spectrometry (SC-ICP-MS), which could provide quantitative information at a single-cell level. The cell digestion method validated the accuracy of the SC-ICP-MS. The concentrations of Gd@C-82(OH)(22) and cisplatin in cells at different exposure times and doses were studied. The SC-ICP-MS is a promising complement to available methods for single cell analysis and is anticipated to be applied further to biomedical research. |
| 学科主题 | Biochemistry & Molecular Biology; Chemistry |
| 类目[WOS] | Biochemical Research Methods ; Chemistry, Analytical |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000351510300005 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228246]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zheng LN,Wang M,Zhao LC,et al. Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2015,407(9):2383-2391. |
| APA | 郑令娜.,王萌.,赵磊超.,孙宝云.,汪冰.,...&Feng, WY.(2015).Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,407(9),2383-2391. |
| MLA | 郑令娜,et al."Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 407.9(2015):2383-2391. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。