Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging
文献类型：期刊论文
| 作者 | Gao FP(高福平) ; Yang WJ(杨文江); Xue JQ(薛井泉); Gao J(高靓); Liu R(刘茹); Wang YL(王亚玲); He X(何潇); Zhao LN(赵丽娜); Zhao YL(赵宇亮); Chai ZF(柴之芳)
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| 刊名 | ACS NANO
 |
| 出版日期 | 2015 |
| 卷号 | 9期号:5页码:4976-4986 |
| 关键词 | (64)copper nanoclusters positron emission tomography imaging orthotopic lung tumor tumor target luteinizing hormone releasing hormone |
| 通讯作者 | 高学云 |
| 英文摘要 | Positron emission tomography (PET) imaging has received special attention owing to its higher sensitivity, temporal resolution, and unlimited tissue penetration. The development of tracers that target specific molecules is therefore essential for the development and utility of clinically relevant PET procedures. However, Cu-64 as a PET imaging agent generally has been introduced into biomaterials through macrocyclic chelators, which may lead to the misinterpretation of PET imaging results due to the detachment and transchelation of Cu-64. In this study, we have developed ultrasmall chelator-free radioactive [Cu-64]Cu nanoclusters using bovine serum albumin (BSA) as a scaffold for PET imaging in an orthotopic lung cancer model. We preconjugated the tumor target peptide luteinizing hormone releasing hormone (LHRH) to BSA molecules to prepare [(64)Ct]Cu-NC@BSA-LHRH. The prepared [Cu-64]Cu nanoclusters showed high radiolabeling stability, ultrasmall size, and rapid deposition and diffusion into tumor, as well as predominantly renal clearance. [Cu-64]Cu-NC@BSA-LHRH showed 4 times higher tumor uptake compared with that of [Cu-64]Cu-NC@BSA by analyzing the Cu-64 radioactivity of tissues via gamma counting. The PET imaging using [Cu-64]Cu nanoclusters as tracers showed more sensitive, accurate, and deep penetration imaging of orthotopic lung cancer in vivo compared with near-infrared fluorescence imaging. The nanoclusters provide biomedical research tools for PET molecular imaging. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000355383000033 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228474]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 高能物理研究所_核技术应用研究中心 |
| 推荐引用方式 GB/T 7714 | Gao FP,Yang WJ,Xue JQ,et al. Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging[J]. ACS NANO,2015,9(5):4976-4986. |
| APA | 高福平.,杨文江.,薛井泉.,高靓.,刘茹.,...&Gao, XY.(2015).Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging.ACS NANO,9(5),4976-4986. |
| MLA | 高福平,et al."Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging".ACS NANO 9.5(2015):4976-4986. |
入库方式： OAI收割
来源：高能物理研究所
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