Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence
文献类型：期刊论文
| 作者 | Chen HQ(陈汉清) ; Wang B(汪冰); Feng WY(丰伟悦); Ou YH(欧阳宏); Chai ZF(柴之芳); Mi XL(秘晓林); Chen, HQ; Wang, B; Feng, WY; Du, W
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| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 9期号:3页码:302-312 |
| 关键词 | Developmental delay Drosophila melanogaster elements dyshomeostasis magnetite nanoparticles oogenesis |
| 通讯作者 | 丰伟悦 |
| 英文摘要 | The potential impacts of nanomaterials (NMs) on fetal development have attracted great concerns because of the increased potential exposure to NMs during pregnancy. Drosophila melanogaster oogenesis and developmental transitions may provide an attractive system to study the biological and environmental effects of NMs on the embryonic development. In this study, the effects of three types of magnetite (Fe3O4) nanoparticles (MNPs): UN-MNPs (pristine), CA-MNPs (citric acid modified) and APTS-MNPs (3-aminopropyltriethoxylsilane coated) on the development of Drosophila at 300 and 600 mu g/g dosage were studied. The uptake of MNPs by female and male flies caused obvious reduction in the female fecundity, and the developmental delay at the egg-pupae and pupae-adult transitions, especially in those treated by the positive APTS-MNPs. Further investigation demonstrates that the parental uptake of MNPs disturbs the oogenesis period, induces ovarian defect, reduces the length of eggs, decreases the number of nurse cells and delays egg chamber development, which may contribute to the decrease of fecundity of female Drosophila and the development delay of their offspring. Using the synchrotron radiation-based micro-X-ray fluorescence (SR-mu XRF), the dyshomeostasis of trace elements such as Fe, Ca and Cu along the anterior-posterior axis of the fertilized eggs was found, which may be an important reason for the development delay of Drosophila. |
| 学科主题 | Science & Technology - Other Topics; Toxicology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Toxicology |
| 收录类别 | SCI ; CA |
| WOS记录号 | WOS:000354975400004 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228508]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Chen HQ,Wang B,Feng WY,et al. Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence[J]. NANOTOXICOLOGY,2015,9(3):302-312. |
| APA | 陈汉清.,汪冰.,丰伟悦.,欧阳宏.,柴之芳.,...&Bi, XL.(2015).Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence.NANOTOXICOLOGY,9(3),302-312. |
| MLA | 陈汉清,et al."Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence".NANOTOXICOLOGY 9.3(2015):302-312. |
入库方式： OAI收割
来源：高能物理研究所
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