Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells
文献类型：期刊论文
| 作者 | Chen HQ(陈汉清) ; Wang B(汪冰); Zheng LN(郑令娜); Zhou XY(周晓燕); Chai ZF(柴之芳); Zhao YL(赵宇亮); Feng WY(丰伟悦); Chen, HQ; Wang, BQ; Zhao, RF
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| 刊名 | SMALL
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| 出版日期 | 2015 |
| 卷号 | 11期号:34页码:4366-4378 |
| 通讯作者 | 丰伟悦 |
| 英文摘要 | Single walled carbon nanotubes (SWCNTs) have been shown to be highly effective against a wide range of bacteria. Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) infection is a well-known mediator to prolong hospitalization and initiate chronic inflammation, yet the biological effects of SWCNTs on the pathogen-infected enterocytes remain unclear. Herein, it is shown that the low-dose SWCNT treatment attenuates the human enterocyte-like Caco-2 cells from the damage of E. coli and S. aureus infection by suppressing NLRP3 inflammasome activation. The relatively low-dose (1 and 10 mu g mL(-1)) SWCNT treatments reduce the adhesion and invasion of E. coli and S. aureus to Caco-2 cells, increase the cell viability and proliferation, reduce the tight junction permeability, and restitute the integrity of cell surface microvilli structure, meanwhile has low cytotoxicity to the host cells. The low-dose SWCNT treatment further reduces the NLRP3-mediated IL-1 beta secretion in the infected cells. The results identify that a low-dose SWCNT treatment serves a protective function for the E. coli- and S. aureus-infected Caco-2 cells by negatively regulating mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000360852900014 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228742]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Chen HQ,Wang B,Zheng LN,et al. Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells[J]. SMALL,2015,11(34):4366-4378. |
| APA | 陈汉清.,汪冰.,郑令娜.,周晓燕.,柴之芳.,...&Feng, WY.(2015).Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells.SMALL,11(34),4366-4378. |
| MLA | 陈汉清,et al."Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells".SMALL 11.34(2015):4366-4378. |
入库方式： OAI收割
来源：高能物理研究所
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