Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner
文献类型：期刊论文
| 作者 | Cheng, XJ; Tian, X; Wu, AQ; Li, JX; Tian, J; Chong, Y; Chai, ZF; Zhao, YL; Chen, CY; Ge, CC |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:37页码:20568-20575 |
| 关键词 | gold nanoparticle size protein corona cell line uptake level endocytic pathways |
| 英文摘要 | The interaction at nanobio is a critical issue in designing safe nanomaterials for biomedical applications. Recent studies have reported that it is nanoparticle-protein corona rather than bare nanoparticle that determines the nanoparticle cell interactions, including endocytic pathway and biological responses. Here, we demonstrate the effects of protein corona on cellular uptake of different sized gold nanoparticles in different cell lines. The experimental results show that protein corona significantly decreases the internalization of Au NPs in a particle size- and cell type-dependent manner. Protein corona exhibits much more significant inhibition on the uptake of large-sized Au NPs by phagocytic cell than that of small-sized Au NPs by nonphagocytic cell. The endocytosis experiment indicates that different endocytic pathways might be responsible for the differential roles of protein corona in the interaction of different sized Au NPs with different cell lines. Our findings can provide useful information for rational design of nanomaterials in biomedical application. |
| 学科主题 | Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI |
| WOS记录号 | WOS:000361931600010 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228784]  |
| 专题 | 高能物理研究所_院士 |
| 推荐引用方式 GB/T 7714 | Cheng, XJ,Tian, X,Wu, AQ,et al. Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(37):20568-20575. |
| APA | Cheng, XJ.,Tian, X.,Wu, AQ.,Li, JX.,Tian, J.,...&柴之芳.(2015).Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner.ACS APPLIED MATERIALS & INTERFACES,7(37),20568-20575. |
| MLA | Cheng, XJ,et al."Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner".ACS APPLIED MATERIALS & INTERFACES 7.37(2015):20568-20575. |
入库方式： OAI收割
来源：高能物理研究所
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