Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand
文献类型：期刊论文
| 作者 | Lu HR(卢会茹); Chen J(陈俊) ; Liu XX(刘潇潇); Wu HC(吴海臣); Zhao YL(赵宇亮); Chai ZF(柴之芳); Hu Y(胡毅); Lu; H.; S. Li
|
| 刊名 | Metallomics
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:11页码:1508-1514 |
| 通讯作者 | 胡毅 |
| 英文摘要 | Small-molecule ligands for stabilizing the G-quadruplex in telomeres are promising chemotherapeutic agents. Despite extensive research, few G-quadruplex-stabilizing ligands have been clinically approved to date. We hypothesized that metal ions may be able to interfere with the ligand-mediated stabilization of the G-quadruplex. Here we found that several metal ions could interfere with the Na+-induced G-quadruplex conformation even in the presence of a ligand. The destabilizing effects of metal ions may not be negligible as most of them are essential elements in organisms. In contrast, Ba2+ was found to be a potent stabilizing cation, which could compete with other destabilizing cations to modulate the stability of the G-quadruplex. Moreover, the destabilizing effects of divalent or trivalent cations were considerably inhibited when a metal chelator was used. These data suggested that the unfavorable effects of destabilizing cations must be minimized for enhancing the ligand-mediated stabilization of the G-quadruplex. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 收录类别 | SCI ; EI ; CA ; MEDLINE |
| WOS记录号 | WOS:000364822500005 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228874]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Lu HR,Chen J,Liu XX,et al. Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand[J]. Metallomics,2015,7(11):1508-1514. |
| APA | 卢会茹.,陈俊.,刘潇潇.,吴海臣.,赵宇亮.,...&Y. Hu.(2015).Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand.Metallomics,7(11),1508-1514. |
| MLA | 卢会茹,et al."Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand".Metallomics 7.11(2015):1508-1514. |
入库方式： OAI收割
来源：高能物理研究所
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