Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster
文献类型：期刊论文
| 作者 | Huang, Baoyu1 ; Zhang, Linlin1; Du, Yishuai1; Li, Li1; Tang, Xueying1,2; Zhang, Guofan1
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| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 48页码:12-19 |
| 关键词 | Pacific oyster Crassostrea gigas TRAF2 Innate immunity MAVS |
| 英文摘要 | Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of crucial adaptors, playing vital roles in mediating signal transduction in immune signaling pathways, including RIG-I-like receptor (RLR) signaling pathway. In the present study, a new TRAF family member (CgTRAF2) was identified in the Pacific oyster, Crassostrea gigas. Comparison and phylogenetic analysis revealed that CgTRAF2 could be a new member of the invertebrate TRAF2 family. Quantitative real-time PCR revealed that CgTRAF2 mRNA was highly expressed in the digestive gland, gills, and hemocytes, and it was significantly up regulated after Vibrio alginolyticus and ostreid herpesvirus 1 (OsHV-1) challenge. The CgTRAF2 mRNA expression profile in different developmental stages of oyster larvae suggested that CgTRAF2 could function in early larval development. CgTRAF2 mRNA expression pattern, after the silence of CgMAVS (Mitochondrial Antiviral Signaling) -like, indicated that CgTRAF2 might function downstream of CgMAVS-like. Moreover, the subcellular localization analysis revealed that CgTRAF2 was localized in cytoplasm, and it may play predominately important roles in signal transduction. Collectively, these results demonstrated that CgTRAF2 might play important roles in the innate immunity and larval development of the Pacific oyster. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368953000002 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/112436]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Baoyu,Zhang, Linlin,Du, Yishuai,et al. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2016,48:12-19. |
| APA | Huang, Baoyu,Zhang, Linlin,Du, Yishuai,Li, Li,Tang, Xueying,&Zhang, Guofan.(2016).Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,48,12-19. |
| MLA | Huang, Baoyu,et al."Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 48(2016):12-19. |
入库方式： OAI收割
来源：海洋研究所
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