Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T
文献类型：期刊论文
| 作者 | Deng, ZW(邓宗武) ; Wang, QB(王强斌); Zhang, HL(张海禄); Dai, JW(戴建武)
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2013-04 |
| 卷号 | 34期号:12页码:3010-3019 |
| 关键词 | MRI hMSCs Fe3O4@SiO2 Single cell sensitivity |
| 通讯作者 | Deng, ZW(邓宗武) |
| 英文摘要 | Fe3O4@SiO2 core-shell nanoparticles were synthesized and used to label human mesenchymal stem cells (hMSCs) for in vitro and in vivo magnetic resonance imaging study. The diameter of the nanoparticles is 24-30 nm with a Fe3O4 core of similar to 8 nm and a SiO2 shell of similar to 8 nm. Transverse relaxivity of the nanoparticles dispersed in water is measured to be similar to 106 mM(-1) s(-1). After incubation with hMSCs for 12 h at a concentration of 100 mu g Fe/mL, cellular uptake of Fe3O4@SiO2 is 20-100 pg Fe/cell, which are located predominantly in the cytoplasm of cells. This level of uptake exhibits no significant influence on hMSCs' viability and differentiation. In vitro imaging of Fe3O4@SiO2-labeled hMSCs evenly distributed in agarose gel yields single cell sensitivity at 11.7 T. In vivo imaging of Fe3O4@SiO2-labeled hMSCs injected into the left brain hemisphere of nude mice yields imaging sensitivity of similar to 130 hMSCs. (C) 2013 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000316038900016 |
| 公开日期 | 2014-01-15 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1362]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队 |
| 通讯作者 | Deng, ZW(邓宗武) |
| 推荐引用方式 GB/T 7714 | Deng, ZW,Wang, QB,Zhang, HL,et al. Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T[J]. BIOMATERIALS,2013,34(12):3010-3019. |
| APA | Deng, ZW,Wang, QB,Zhang, HL,&Dai, JW.(2013).Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T.BIOMATERIALS,34(12),3010-3019. |
| MLA | Deng, ZW,et al."Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T".BIOMATERIALS 34.12(2013):3010-3019. |
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