In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent
文献类型：期刊论文
| 作者 | Dai, JW (戴建武) ; Deng, ZW (邓宗武); Zhang, HL (张海禄)
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
 |
| 出版日期 | 2014-01 |
| 卷号 | 33期号:1页码:215-220 |
| 关键词 | Arg-Gly-Asp Asn-Gly-Arg dual targeting ast agent magnetic resonance imaging contr |
| 通讯作者 | Yu, KC (Yu, Kaichao) |
| 英文摘要 | In this study, a peptide-based dual-targeting magnetic resonance imaging (MRI) contrast agent (S8) was designed and synthesized. Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) were combined in the targeting vector so as to allow binding, on the surface of tumor cells, to integrin (v3) and aminopeptidase N (CD13), respectively. The longitudinal relaxivity (r(1)) value of S8 was 8.297 mM(-1)sec(-1) at a magnetic field of 11.7 T, which is approximately double the r(1) value (4.25 mM(-1)sec(-1)) of Magnevist, a commercially available contrast agent. MDA-MB-231 human breast cancer cells (which overexpress (v3)) and human prostate cancer cells PC-3 (which overexpress CD13) were used to investigate the tumor-targeting behavior of S8. The results from the present study indicate that the designed contrast agent, S8, targets both MDA-MB-231 and PC-3 cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330785400028 |
| 公开日期 | 2014-12-19 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1690]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队 |
| 推荐引用方式 GB/T 7714 | Dai, JW ,Deng, ZW ,Zhang, HL . In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2014,33(1):215-220. |
| APA | Dai, JW ,Deng, ZW ,&Zhang, HL .(2014).In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,33(1),215-220. |
| MLA | Dai, JW ,et al."In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 33.1(2014):215-220. |
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