The interplay of T-1- and T-2-relaxation on T-1-weighted MRI of hMSCs induced by Gd-DOTA-peptides
文献类型：期刊论文
| 作者 | Deng, ZW (邓宗武) ; Dai, JW (戴建武); Zhang, HL (张海禄)
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2014 |
| 卷号 | 35期号:13页码:4168-4174 |
| 关键词 | MRI Gd-DOTA-peptides hMSCs T-1 enhancement Relaxivity |
| 通讯作者 | Tan, B (谭波) |
| 英文摘要 | Three Gd-DOTA-peptide complexes with different peptide sequence are synthesized and used as T-1 contrast agent to label human mesenchymal stem cells (hMSCs) for magnetic resonance imaging study. The peptides include a universal cell penetrating peptide TAT, a linear MSC-specific peptide EM7, and a cyclic MSC-specific peptide CC9. A significant difference in labeling efficacy is observed between the Gd-DOTA-peptides as well as a control Dotarem. All Gd-DOTA-peptides as well as Dotarem induce significant increase in T-1 relaxation rate which is in favor of T-1-weighted MR imaging. Gd-DOTA-CC9 yields the maximum labeling efficacy but poor T1 contrast enhancement. Gd-DOTA-EM7 yields the minimum labeling efficacy but better T-1 contrast enhancement. Gd-DOTA-TAT yields a similar labeling efficacy as GdDOTA-CC9 and similar T-1 contrast enhancement as Gd-DOTA-EM7. The underlying mechanism that governs T-1 contrast enhancement effect is discussed. Our results suggest that T-1 contrast enhancement induced by Gd-DOTA-peptides depends not only on the introduced cellular Gd content, but more importantly on the effect that Gd-DOTA-peptides exert on the T-1-relaxation and T-2-relaxation processes/ rates. Both T-1 and particularly T-2 relaxation rate have to be taken into account to interpret T-1 contrast enhancement. In addition, the interpretation has to be based on cellular instead of aqueous longitudinal and transverse relaxivities of Gd-DOTA-peptides. (c) 2014 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334481000025 |
| 公开日期 | 2015-02-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1805]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队 |
| 推荐引用方式 GB/T 7714 | Deng, ZW ,Dai, JW ,Zhang, HL . The interplay of T-1- and T-2-relaxation on T-1-weighted MRI of hMSCs induced by Gd-DOTA-peptides[J]. BIOMATERIALS,2014,35(13):4168-4174. |
| APA | Deng, ZW ,Dai, JW ,&Zhang, HL .(2014).The interplay of T-1- and T-2-relaxation on T-1-weighted MRI of hMSCs induced by Gd-DOTA-peptides.BIOMATERIALS,35(13),4168-4174. |
| MLA | Deng, ZW ,et al."The interplay of T-1- and T-2-relaxation on T-1-weighted MRI of hMSCs induced by Gd-DOTA-peptides".BIOMATERIALS 35.13(2014):4168-4174. |
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