Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction
文献类型：期刊论文
| 作者 | Yang, Y; Shi, CY; Hou, XL; Zhao, YN; Chen, B; Tan, B(谭波); Deng, ZW(邓宗武) ; Li, QG; Liu, JZ; Xiao, ZF
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| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2015 |
| 卷号 | 213页码:9 |
| 关键词 | VEGF Myocardial infarction Drug delivery Targeting therapy |
| 通讯作者 | Dai, JW (戴建武) |
| 英文摘要 | Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after myocardial infarction (MI). However, the non-targeted delivery of VEGF decreases its therapeutic efficacy due to an insufficient local concentration in the ischemic myocardium. In this study, we used a specific peptide to modify VEGF and determined that this modified VEGF (IMT-VEGF) localized to the ischemic myocardium through intravenous injection by interacting with cardiac troponin I (cTnI). When IMT-VEGF was used to mediate cardiac repair in a rat model of ischemia-reperfusion (I-R) injury, we observed a decreased scar size, enhanced angiogenesis and improved cardiac function. Moreover, an alternative treatment using the repeated administration of a low-dose IMT-VEGF also promoted angiogenesis and functional recovery. The therapeutic effects of IMT-VEGF were further confirmed in a pig model of MI as the result of the conserved properties of its interacting protein, cTnI. These results suggest a promising therapeutic strategy for MI based on the targeted delivery of IMT-VEGF. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/3313]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队 |
| 推荐引用方式 GB/T 7714 | Yang, Y,Shi, CY,Hou, XL,et al. Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction[J]. JOURNAL OF CONTROLLED RELEASE,2015,213:9. |
| APA | Yang, Y.,Shi, CY.,Hou, XL.,Zhao, YN.,Chen, B.,...&Dai, JW.(2015).Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction.JOURNAL OF CONTROLLED RELEASE,213,9. |
| MLA | Yang, Y,et al."Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction".JOURNAL OF CONTROLLED RELEASE 213(2015):9. |
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