Preparation and thermodynamic properties of Felodipine form IV
文献类型：期刊论文
| 作者 | Wang, L; Song, YJ(宋越军); Yang, P; Tan, B(谭波); Zhang, HL(张海禄); Deng, ZW(邓宗武) |
| 刊名 | JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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| 出版日期 | 2015 |
| 卷号 | 120期号:1页码:5 |
| 关键词 | Felodipine Polymorphism Thermodynamic properties Physicochemical properties Phase transformation |
| 通讯作者 | Yang, P |
| 英文摘要 | Form IV of the calcium channel blocker, Felodipine was obtained consistently via solvent evaporation in a pH-controlled solution, and followed by large-scale crystallization through seeding the saturated solution of Felodipine. Comparing with form I, the crystal form used in the marketed products, form IV has higher melting temperature but lower melting enthalpy. Hence, according to the heat of fusion rule, polymorphs I and IV should be in an enantiotropic relationship. Form I is thermodynamically more stable than form IV at room temperature. Their theoretical polymorphic transformation temperature was estimated at 87.6 A degrees C, which was also confirmed by the solvent-mediated polymorphic transformation experiments. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/3398]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 |
| 推荐引用方式 GB/T 7714 | Wang, L,Song, YJ,Yang, P,et al. Preparation and thermodynamic properties of Felodipine form IV[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2015,120(1):5. |
| APA | Wang, L,Song, YJ,Yang, P,Tan, B,Zhang, HL,&Deng, ZW.(2015).Preparation and thermodynamic properties of Felodipine form IV.JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,120(1),5. |
| MLA | Wang, L,et al."Preparation and thermodynamic properties of Felodipine form IV".JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 120.1(2015):5. |
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