Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery
文献类型：期刊论文
| 作者 | Jin, J (靳健)
|
| 刊名 | JOURNAL OF NANO RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 27期号:0页码:75-81 |
| 关键词 | fibroin nanoparticles drug delivery Antheraea pernyi Doxorubicin hydrochloride |
| 通讯作者 | Jin, J (靳健) |
| 英文摘要 | Silk nanoparticles were easily obtained from regenerated Antheraea Pernyi Silk Fibroin (ASF). The morphology and average size of the silk particles was sensitive to pH value of fibroin solution. The diameter of nanoparticles prepared was in the range of 30 nm to 1000 nm with a narrow size distribution. On this process, the molecular conformation of regenerated ASP changed from a-helix to beta-sheet structure. The shape of prepared nanoparticles were regular spherical structure when the pH value was about 4.3 (pI) in ASF solution. Doxorubicin hydrochloride (DOX) was loaded in the ASP particles as drug release model and the drug-loading ratio was 3.4 %. The release rate of DOX from ASF nanoparticles was pH sensitive. After 23 days release, there was still 84% DOX in the ASP nanoparticles. The result suggested that the ASF nanoparticles might be suitable microcarriers for drug delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339303600009 |
| 公开日期 | 2015-02-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1738]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_靳健团队 |
| 通讯作者 | Jin, J (靳健) |
| 推荐引用方式 GB/T 7714 | Jin, J . Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery[J]. JOURNAL OF NANO RESEARCH,2014,27(0):75-81. |
| APA | Jin, J .(2014).Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery.JOURNAL OF NANO RESEARCH,27(0),75-81. |
| MLA | Jin, J ."Antheraea Pernyi Silk Fibroin Nanoparticles for Drug Delivery".JOURNAL OF NANO RESEARCH 27.0(2014):75-81. |
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