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Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs
文献类型：期刊论文
| 作者 | Liu LW (刘立伟) ; Zhang ZJ (张智军)
|
| 刊名 | Small
 |
| 出版日期 | 2010-02-22 |
| 期号 | 4 |
| 关键词 | cancer therapy cytotoxicity drug delivery graphene oxide nanomaterials |
| 通讯作者 | Zhang ZJ (张智军) |
| 合作状况 | 其它 |
| 英文摘要 | A simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by covalent binding of folic acid (FA) molecules to the NGO, thus allowing it to specifically target MCF-7 cells, human breast cancer cells with FA receptors. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT), onto the FA-conjugated NGO (FA-NGO) via pi-pi stacking and hydrophobic interactions is investigated. It is demonstrated that FA-NGO loaded with the two anticancer drugs shows specific targeting to MCF-7 cells, and remarkably high cytotoxicity compared to NGO loaded with either DOX or CPT only. Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene-based nanocarriers may find widespread application in biomedicine. |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275260100009 |
| 公开日期 | 2010-12-31 |
| 源URL | [http://58.210.77.100/handle/332007/289]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 苏州纳米技术与纳米仿生研究所_纳米器件及相关材料研究部_刘立伟团队 |
| 通讯作者 | Zhang ZJ (张智军) |
| 推荐引用方式 GB/T 7714 | Liu LW ,Zhang ZJ . Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs[J]. Small,2010(4). |
| APA | Liu LW ,&Zhang ZJ .(2010).Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs.Small(4). |
| MLA | Liu LW ,et al."Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs".Small .4(2010). |
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