Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process
文献类型：期刊论文
| 作者 | Cheng, GS（程国胜）
|
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2013-04 |
| 卷号 | 15期号:4 |
| 关键词 | Quantum dots Neurotoxicity Hippocampus Synaptic plasticity Spatial memory |
| 通讯作者 | Wang, M |
| 英文摘要 | Studies reported that quantum dots (QDs), as a novel probe, demonstrated a promising future for in vivo imaging, but also showed potential toxicity. This study is mainly to investigate in vivo response in the central nervous system(CNS) after exposure to QDs in a rat model of synaptic plasticity and spatial memory. Adult rats were exposed to streptavidin-conjugated CdSe/ZnS QDs (Qdots 525, purchased from Molecular Probes Inc.) by intraperitoneal injection for 7 days, followed by behavioral, electrophysiological, and biochemical examinations. The electrophysiological results show that input/output (I/O) functions were increased, while the peak of paired-pulse reaction and long-term potentiation were decreased after QDs insult, indicating synaptic transmission was enhanced and synaptic plasticity in the hippocampus was impaired. Meanwhile, behavioral experiments provide the evidence that QDs could impair rats' spatial memory process. All the results present evidences of interference of synaptic transmission and plasticity in rat hippocampal dentate gyrus area by QDs insult and suggest potential adverse issues which should be considered in QDs applications. |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318554400073 |
| 公开日期 | 2014-01-15 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1410]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_程国胜团队 |
| 推荐引用方式 GB/T 7714 | Cheng, GS. Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process[J]. JOURNAL OF NANOPARTICLE RESEARCH,2013,15(4). |
| APA | Cheng, GS.(2013).Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process.JOURNAL OF NANOPARTICLE RESEARCH,15(4). |
| MLA | Cheng, GS."Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process".JOURNAL OF NANOPARTICLE RESEARCH 15.4(2013). |
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