The acute cytotoxicity of bismuth ferrite nanoparticles on PC12 cells
文献类型：期刊论文
| 作者 | Song Q(宋琴) ; Cheng GS(程国胜)
|
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 16期号:5 |
| 关键词 | BiFeO3 Biocompatibility Cytotoxicity Environmental and health effects |
| 通讯作者 | 程国胜 |
| 英文摘要 | Due to its unique properties, bismuth ferrite (BiFeO3, BFO) has gained a great deal of interest. The prevalence of BFO increases the likelihood of exposures either to environment or to humans. Unfortunately, the understanding of BFO biological effects is very limited. In this study, a battery of standard tests, such as morphology observation, MTT, and LDH assay, and flow cytometry analysis, was employed to elucidate in vitro cytotoxicity of BFO nanoparticles (NPs) in the size range of 30-90 nm using PC12 cells as a model. The results show that BFO-NPs could tightly attach to the cell membrane in the culture medium, which significantly affect the cell adhesion and inhibit their proliferation. Moreover, cytotoxicity of BFO-NPs is greatly mitigated when the exposure time was extended to 48 h. These findings suggest that BFO-NP possess the nature of acute cytotoxicity since the cells can recover to a certain extent over with incubation time. For the first time, our study reveals some essential properties of BFO-NP toxicity, which may advance BFO applications and its toxicological study. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335562400001 |
| 公开日期 | 2014-12-08 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1682]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_程国胜团队 |
| 推荐引用方式 GB/T 7714 | Song Q,Cheng GS. The acute cytotoxicity of bismuth ferrite nanoparticles on PC12 cells[J]. JOURNAL OF NANOPARTICLE RESEARCH,2014,16(5). |
| APA | Song Q,&Cheng GS.(2014).The acute cytotoxicity of bismuth ferrite nanoparticles on PC12 cells.JOURNAL OF NANOPARTICLE RESEARCH,16(5). |
| MLA | Song Q,et al."The acute cytotoxicity of bismuth ferrite nanoparticles on PC12 cells".JOURNAL OF NANOPARTICLE RESEARCH 16.5(2014). |
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