Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates
文献类型：期刊论文
| 作者 | Chen, LW(陈立桅) ; Wang, QB(王强斌); Dai, JW(戴建武)
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:26页码:6139-6146 |
| 关键词 | Atomic force microscopy Collagen binding domain Dissociation constant Collagen membrane Dissociation constant AFM force spectroscopy AFM force spectroscopy Growth factor |
| 通讯作者 | Chen, LW(陈立桅) |
| 英文摘要 | Biological studies have shown that collagen/collagen binding domain (CBD)-growth factor composites are effective biomaterials systems for tissue engineering and regeneration. Here we present atomic force spectroscopy (AFM)-based investigations at the single molecule level to address fundamental biophysical questions such as CBD binding sites distribution and the mechanism for controlled release of growth factors from the collagen scaffold. Non-uniformly distributed CBD binding sites on collagen membrane are directly visualized with a quantum dot-based bimodal imaging method. AFM force spectroscopy unbinding experiments reveal that modest unbinding force and dissociation constant of the CBD/collagen interaction could be the key for its successful application in controlled release systems |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321079600006 |
| 公开日期 | 2014-01-15 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1396]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米研究国际实验室_陈立桅团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队 |
| 通讯作者 | Chen, LW(陈立桅) |
| 推荐引用方式 GB/T 7714 | Chen, LW,Wang, QB,Dai, JW. Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates[J]. BIOMATERIALS,2013,34(26):6139-6146. |
| APA | Chen, LW,Wang, QB,&Dai, JW.(2013).Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates.BIOMATERIALS,34(26),6139-6146. |
| MLA | Chen, LW,et al."Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates".BIOMATERIALS 34.26(2013):6139-6146. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。