Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model
文献类型：期刊论文
| 作者 | Dai, JW (戴建武)
|
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2014 |
| 卷号 | 57期号:2页码:232-240 |
| 关键词 | collagen scaffold basic fibroblast growth factor spinal cord injury nerve regeneration |
| 通讯作者 | Dai, JW (戴建武) |
| 英文摘要 | Nerve conduit is one of strategies for spine cord injury (SCI) treatment. Recently, studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury site. However, the scaffold by itself was difficult to meet the need of SCI functional recovery. The basic fibroblast growth factor (bFGF) administration significantly promotes functional recovery after organ injuries. Here, using a rat model of T9 hemisected SCI, we aimed at assessing the repair capacity of implantation of collagen scaffold (CS) modified by collagen binding bFGF (CBD-bFGF). The results showed that CS combined with CBD-bFGF treatment improved survival rates after the lateral hemisection SCI. The CS/CBD-bFGF group showed more significant improvements in motor than the simply CS-implanted and untreated control group, when evaluated by the 21-point Basso-Beattie-Bresnahan (BBB) score and footprint analysis. Both hematoxylin and eosin (H&E) and immunohistochemical staining of neurofilament (NF) and glial fibrillary acidic protein (GFAP) demonstrated that fibers were guided to grow through the implants. These findings indicated that administration of CS modified with CBD-bFGF could promote spinal cord regeneration and functional recovery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331206000011 |
| 公开日期 | 2015-02-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1768]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队 |
| 通讯作者 | Dai, JW (戴建武) |
| 推荐引用方式 GB/T 7714 | Dai, JW . Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(2):232-240. |
| APA | Dai, JW .(2014).Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model.SCIENCE CHINA-LIFE SCIENCES,57(2),232-240. |
| MLA | Dai, JW ."Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model".SCIENCE CHINA-LIFE SCIENCES 57.2(2014):232-240. |
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