Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases
文献类型：期刊论文
| 作者 | Lu, YD(卢煜东); Li, Z; Teng, H; Xu, HK(徐宏科); Qi, SN; He, JA; Gu, DY; Chen, QJ; Ma, HW(马宏伟) |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5页码:11 |
| 通讯作者 | Chen, QJ |
| 英文摘要 | Linear B-cell epitopes are ideal biomarkers for the serodiagnosis of infectious diseases. However, the long-predicted diagnostic value of epitopes has not been realized. Here, we demonstrated a method, diagnostic epitopes in four steps (DEIFS), that delivers a combination of epitopes for the serodiagnosis of infectious diseases with a high success rate. Using DEIFS for malaria, we identified 6 epitopes from 8 peptides and combined them into 3 chimeric peptide constructs. Along with 4 other peptides, we developed a rapid diagnostic test (RDT), which is able to differentiate Plasmodium falciparum (P. falciparum) from Plasmodium vivax (P. vivax) infections with 95.6% overall sensitivity and 99.1% overall specificity. In addition to applications in diagnosis, DEIFS could also be used in the diagnosis of virus and bacterium infections, discovery of vaccine candidates, evaluation of vaccine potency, and study of disease progression. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/3327]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_马宏伟团队 |
| 推荐引用方式 GB/T 7714 | Lu, YD,Li, Z,Teng, H,et al. Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases[J]. SCIENTIFIC REPORTS,2015,5:11. |
| APA | Lu, YD.,Li, Z.,Teng, H.,Xu, HK.,Qi, SN.,...&Ma, HW.(2015).Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases.SCIENTIFIC REPORTS,5,11. |
| MLA | Lu, YD,et al."Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases".SCIENTIFIC REPORTS 5(2015):11. |
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