Label-Free Logic Modules and Two-Layer Cascade Based on Stem-Loop Probes Containing a G-Quadruplex Domain
文献类型：期刊论文
| 作者 | Pei RJ(裴仁军)
|
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2014-09 |
| 卷号 | 9期号:9页码:2397-2401 |
| 关键词 | DNA computing G quadruplexes label-free detection logic gates multiple-input cascade |
| 通讯作者 | Hu, JM |
| 英文摘要 | A simple, versatile, and label-free DNA computing strategy was designed by using toehold-mediated strand displacement and stem-loop probes. A full set of logic gates (YES, NOT, OR, NAND, AND, INHIBIT, NOR, XOR, XNOR) and a two-layer logic cascade were constructed. The probes contain a G-quadruplex domain, which was blocked or unfolded through inputs initiating strand displacement and the obviously distinguishable light-up fluorescent signal of G-quadruplex/NMM complex was used as the output readout. The inputs are the disease-specific nucleotide sequences with potential for clinic diagnosis. The developed versatile computing system based on our label-free and modular strategy might be adapted in multi-target diagnosis through DNA hybridization and aptamer-target interaction. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342677400005 |
| 公开日期 | 2014-12-01 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1616]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队 |
| 推荐引用方式 GB/T 7714 | Pei RJ. Label-Free Logic Modules and Two-Layer Cascade Based on Stem-Loop Probes Containing a G-Quadruplex Domain[J]. CHEMISTRY-AN ASIAN JOURNAL,2014,9(9):2397-2401. |
| APA | Pei RJ.(2014).Label-Free Logic Modules and Two-Layer Cascade Based on Stem-Loop Probes Containing a G-Quadruplex Domain.CHEMISTRY-AN ASIAN JOURNAL,9(9),2397-2401. |
| MLA | Pei RJ."Label-Free Logic Modules and Two-Layer Cascade Based on Stem-Loop Probes Containing a G-Quadruplex Domain".CHEMISTRY-AN ASIAN JOURNAL 9.9(2014):2397-2401. |
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