Label-free Detection of Zn2+ Based on G-quadruplex
文献类型：期刊论文
| 作者 | Guo, YH(郭亚辉); Sun, Y(孙艳); Shen, XQ(申小强); Zhang, KC(张坤驰); Hu, JM; Pei, RJ(裴仁军) |
| 刊名 | ANALYTICAL SCIENCES
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:10页码:5 |
| 关键词 | G-quadruplex thioflavin T Zn2+ detection label-free |
| 通讯作者 | Hu, JM |
| 英文摘要 | Herein, we developed a sensing strategy for the label-free detection of Zn2+ based on G-quadruplex. In the absence of Zn2+, there was a fluorescence enhancement of thioflavin T by interaction with human telomere sequence. On the addition of Zn2+, Zn2+ induced a more compact G-quadruplex structure to release thioflavin T, resulting in a fluorescence decrease. This simple "mix-then-detect" method gave the detection limit of 0.91 mu M with linear dynamic ranges from 0 to 10 mu M. Because it does not require the use of expensive and unstable DNAzyme systems, or need synthesis and modification of nanomaterials, this label-free biosensor is simple, fast, cost-effective and applicable for real samples taken from lake water. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/3297]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队 |
| 推荐引用方式 GB/T 7714 | Guo, YH,Sun, Y,Shen, XQ,et al. Label-free Detection of Zn2+ Based on G-quadruplex[J]. ANALYTICAL SCIENCES,2015,31(10):5. |
| APA | Guo, YH,Sun, Y,Shen, XQ,Zhang, KC,Hu, JM,&Pei, RJ.(2015).Label-free Detection of Zn2+ Based on G-quadruplex.ANALYTICAL SCIENCES,31(10),5. |
| MLA | Guo, YH,et al."Label-free Detection of Zn2+ Based on G-quadruplex".ANALYTICAL SCIENCES 31.10(2015):5. |
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