Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Zhang, KC(张坤驰); Liu, M(刘敏); Tong, XY(仝晓艳); Sun, N(孙娜); Zhou, L(周璐); Cao, Y(曹翼); Wang, JE(王金娥); Zhang, HL(张海禄); Pei, RJ(裴仁军) |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:9页码:6 |
| 通讯作者 | Zhang, HL (张海禄) |
| 英文摘要 | A novel aptamer modified thermosensitive liposome was designed as an efficient magnetic resonance imaging probe. In this paper, Gd-DTPA was encapsulated into an optimized thermosensitive liposome (TSL) formulation, followed by conjugation with AS1411 for specific targeting against tumor cells that overexpress nucleolin receptors. The resulting liposomes were extensively characterized in vitro as a contrast agent. As-prepared TSLs-AS1411 had a diameter about 136.1 nrn. No obvious cytotoxicity was observed from MTT assay, which illustrated that the liposomes exhibited excellent biocompatibility. Compared to the control incubation at 37 degrees C, the liposomes modified with AS1411 exhibited much higher T-1 relaxivity in MCF-7 cells incubated at 42 degrees C. These data indicate that the Gd-encapsulated TSLs-AS1411 may be a promising tool in early cancer diagnosis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/3319]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队 |
| 推荐引用方式 GB/T 7714 | Zhang, KC,Liu, M,Tong, XY,et al. Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging[J]. BIOMACROMOLECULES,2015,16(9):6. |
| APA | Zhang, KC.,Liu, M.,Tong, XY.,Sun, N.,Zhou, L.,...&Pei, RJ.(2015).Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging.BIOMACROMOLECULES,16(9),6. |
| MLA | Zhang, KC,et al."Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging".BIOMACROMOLECULES 16.9(2015):6. |
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