Telomerase Expression Abrogates Rapamycin-Induced Irreversible Growth Arrest of Uterine Fibroid Smooth Muscle Cells
文献类型：期刊论文
| 作者 | Suo GL(索广力)
|
| 刊名 | REPRODUCTIVE SCIENCES
 |
| 出版日期 | 2014-09 |
| 卷号 | 21期号:9页码:1161-1170 |
| 关键词 | telomerase rapamycin leiomyoma |
| 通讯作者 | 索广力 |
| 英文摘要 | Uterine fibroids are the most common solid tumors found in women of reproductive age. It has been reported that deregulation of the mammalian target of rapamycin (mTOR) pathway plays an important role in the etiology of leiomyoma. Here, we investigated the effect of rapamycin, an inhibitor of mTORC1, on the growth of primary fibroid smooth muscle cells (fSMCs) and human telomerase reverse transcriptase (hTERT)-transduced and immortalized fSMCs. With the primary fSMCs, a 24-hour treatment with rapamycin was sufficient to trigger a growth arrest that was not reversible upon drug removal. By contrast, the growth inhibitory effect of rapamycin on the hTERT-transduced fSMCs was readily reversible, as these cells resumed proliferation upon the withdrawal of the drug. These results suggest that rapamycin-induced irreversible growth arrest of fSMCs is dependent on the senescence barrier that is abrogated by the ectopic expression of telomerase. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-12-01 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1617]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_索广利团队 |
| 推荐引用方式 GB/T 7714 | Suo GL. Telomerase Expression Abrogates Rapamycin-Induced Irreversible Growth Arrest of Uterine Fibroid Smooth Muscle Cells[J]. REPRODUCTIVE SCIENCES,2014,21(9):1161-1170. |
| APA | Suo GL.(2014).Telomerase Expression Abrogates Rapamycin-Induced Irreversible Growth Arrest of Uterine Fibroid Smooth Muscle Cells.REPRODUCTIVE SCIENCES,21(9),1161-1170. |
| MLA | Suo GL."Telomerase Expression Abrogates Rapamycin-Induced Irreversible Growth Arrest of Uterine Fibroid Smooth Muscle Cells".REPRODUCTIVE SCIENCES 21.9(2014):1161-1170. |
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