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Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice
文献类型：期刊论文
| 作者 | Wang, QB(王强斌)
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013-03 |
| 卷号 | 34期号:14页码:3639-3646 |
| 关键词 | Ag2S quantum dots Pharmacokinetics Biocompatibility Biodistribution Toxicology |
| 通讯作者 | Wang, QB(王强斌) |
| 英文摘要 | Ag2S quantum dots (QDs) have been demonstrated as a promising near-infrared II (NIR-II, 1.0–1.4 μm) emitting nanoprobe for in vivo imaging and detection. In this work, we carefully study the long-term in vivobiodistribution of Ag2S QDs functionalized with polyethylene glycol (PEG) and systematically examine the potential toxicity of Ag2S QDs over time. Our results show that PEGylated-Ag2S QDs are mainly accumulated in the reticuloendothelial system (RES) including liver and spleen after intravenous administration and can be gradually cleared, mostly by fecal excretion. PEGylated-Ag2S QDs do not cause appreciable toxicity at our tested doses (15 and 30 mg/kg) to the treated mice over a period of 2 months as evidenced by blood biochemistry, hematological analysis and histological examinations. Our work lays a solid foundation for further biomedical applications of Ag2S QDs as an important in vivo imaging agent in the NIR-II region. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317534200010 |
| 公开日期 | 2014-01-08 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1255]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队 |
| 通讯作者 | Wang, QB(王强斌) |
| 推荐引用方式 GB/T 7714 | Wang, QB. Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice[J]. BIOMATERIALS,2013,34(14):3639-3646. |
| APA | Wang, QB.(2013).Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice.BIOMATERIALS,34(14),3639-3646. |
| MLA | Wang, QB."Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice".BIOMATERIALS 34.14(2013):3639-3646. |
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