A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system
文献类型：期刊论文
| 作者 | Zhang XY ; Chen FH(陈凤华） ; Ni JZ |
| 刊名 | DRUG DELIVERY
 |
| 出版日期 | 2009-07 |
| 卷号 | 16期号:3页码:280-288 |
| 关键词 | Methotrexate magnetite chitosan microspheres magnetic targeting drug delivery |
| 通讯作者 | Zhang XY |
| 合作状况 | 其它 |
| 英文摘要 | The purpose of the present study is to develop a new method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. MTX was first conjugated to the chitosan chain via a peptide bond and then a suspension cross-linking technique was used for the production of magnetic chitosan microspheres with glutaraldehyde as the cross-linker. The MTX-loading capacity of the magnetic chitosan microspheres was determined and drug release experiments were also carried out to discuss the MTX release behavior. All the data support that the magnetic chitosan-MTX microspheres prepared in this method would have great potential application in magnetic targeting drug delivery technology. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268575100008 |
| 公开日期 | 2010-01-15 |
| 源URL | [http://58.210.77.100/handle/332007/166]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 |
| 推荐引用方式 GB/T 7714 | Zhang XY,Chen FH,Ni JZ. A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system[J]. DRUG DELIVERY,2009,16(3):280-288. |
| APA | Zhang XY,Chen FH,&Ni JZ.(2009).A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system.DRUG DELIVERY,16(3),280-288. |
| MLA | Zhang XY,et al."A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system".DRUG DELIVERY 16.3(2009):280-288. |
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