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Composites of Aminodextran-Coated Fe3O4 Nanoparticles and Graphene Oxide for Cellular Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Zhang, ZJ (张智军) ; Deng, ZW (邓宗武); Zhang, ZJ (张智军)
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2011-10 |
| 卷号 | 3期号:10页码:4085-4091 |
| 关键词 | graphene oxide Fe3O4 nanoparticles composites MRI cell labeling |
| 通讯作者 | Zhang, ZJ (张智军) |
| 英文摘要 | Formation of composites of dextran-coated Fe3O4 nanoparticles (NPs) and graphene oxide (Fe3O4-GO) and their application as T-2-weighted contrast agent for efficient cellular magnetic resonance imaging (MRI) are reported. Aminodextran (AMID) was first synthesized by coupling reaction of carboxymethyldextran with butanediamine, which was then chemically conjugated to meso-2,3-dimercaptosuccinnic acid-modified Fe3O4 NPs. Next, the AND-coated Fe3O4 NPs were anchored onto GO Sheets via formation of amide bond in the presence of 1-ethyl-3-(3-dimethyaminopropyl) carbodiimide (EDC). It is found that the Fe3O4-GO composites possess good physiological stability and low cytotoxicity. Prussian Blue staining analysis indicates that the Fe3O4-GO nanocomposites can be internalized efficiently by HeLa cells, depending on the concentration of the composites incubated with the cells. Furthermore, compared with the isolated Fe3O4 NPs, the Fe3O4-GO composites show significantly enhanced cellular MRI, being capable of detecting cells at the iron concentration of 5 mu g mL(-1) with cell density of 2 x 10(5) cells mL(-1), and at the iron concentration of 20 mu g mL(-1) with cell density of 1000 cells mL(-1). |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296128500041 |
| 公开日期 | 2012-07-24 |
| 源URL | [http://58.210.77.100/handle/332007/506]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 |
| 通讯作者 | Zhang, ZJ (张智军); Zhang, ZJ (张智军) |
| 推荐引用方式 GB/T 7714 | Zhang, ZJ ,Deng, ZW ,Zhang, ZJ . Composites of Aminodextran-Coated Fe3O4 Nanoparticles and Graphene Oxide for Cellular Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2011,3(10):4085-4091. |
| APA | Zhang, ZJ ,Deng, ZW ,&Zhang, ZJ .(2011).Composites of Aminodextran-Coated Fe3O4 Nanoparticles and Graphene Oxide for Cellular Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,3(10),4085-4091. |
| MLA | Zhang, ZJ ,et al."Composites of Aminodextran-Coated Fe3O4 Nanoparticles and Graphene Oxide for Cellular Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 3.10(2011):4085-4091. |
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