Synthesis, protein delivery, and in vitro and in vivo toxicity of a biodegradable poly(aminoester)
文献类型：期刊论文
| 作者 | Zhang, ZJ（张智军） ; Huang, J（黄洁）
|
| 刊名 | TOXICOLOGY RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 2期号:6页码:379-387 |
| 关键词 | WALL CARBON NANOTUBES GENE DELIVERY PLASMID DNA POLYETHYLENIMINE HYDROGELS |
| 通讯作者 | Zhang, ZJ（张智军） |
| 英文摘要 | A hydrolytically degradable poly(amino ester) is synthesized and evaluated as a protein delivery vector in vitro. The poly(amino ester), with cleavable ester bonds, can degrade into nontoxic products both in vitro and in vivo under physiological conditions, exhibiting low toxicity. Our experiments reveal that the poly(amino ester) can efficiently condense proteins via electrostatic interaction, and is significantly less toxic than PEI 25 kDa. Using fluorescein isothiocyanate (FITC) labeled bovine serum albumin and ribonuclease A as model proteins, the degradable poly(amino ester) can efficiently deliver proteins into cells and regulate cell functions. These results suggest that the degradable poly(amino ester) is a promising and efficient protein delivery vector. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325370800002 |
| 公开日期 | 2014-01-15 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1392]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 |
| 通讯作者 | Zhang, ZJ（张智军） |
| 推荐引用方式 GB/T 7714 | Zhang, ZJ,Huang, J. Synthesis, protein delivery, and in vitro and in vivo toxicity of a biodegradable poly(aminoester)[J]. TOXICOLOGY RESEARCH,2013,2(6):379-387. |
| APA | Zhang, ZJ,&Huang, J.(2013).Synthesis, protein delivery, and in vitro and in vivo toxicity of a biodegradable poly(aminoester).TOXICOLOGY RESEARCH,2(6),379-387. |
| MLA | Zhang, ZJ,et al."Synthesis, protein delivery, and in vitro and in vivo toxicity of a biodegradable poly(aminoester)".TOXICOLOGY RESEARCH 2.6(2013):379-387. |
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