Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells
文献类型：期刊论文
| 作者 | Wang, AX; Pu, KF（濮科锋）; Dong, B（董兵）; Liu, Y（刘扬）; Zhang, LM（张立明）; Zhang, ZJ（张智军） ; Duan, W; （王安欣）; Zhu, YM（朱毅敏）
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| 刊名 | JOURNAL OF APPLIED TOXICOLOGY
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| 出版日期 | 2013 |
| 卷号 | 33期号:10页码:1156-1164 |
| 关键词 | graphene oxide cytotoxicity genotoxicity oxidative stress electronic charge |
| 通讯作者 | Zhu, YM（朱毅敏） |
| 英文摘要 | Recently, attempts have been made to apply graphene oxide (GO) in the field of biology and medicine, such as DNA sensing and drug delivery with some necessary modifications. Therefore, the toxicity of GO must be evaluated before it is applied further in biomedicine. In this paper, the cytotoxicity and genotoxicity of GO to human lung fibroblast (HLF) cells have been assessed with methyl thiazolyl tetrazolium (MTT), sub-G1 measurement and comet assays, and the mechanism of its toxicity has been explored. Various modifications of GO have been made to help us determine the factors which could affect the toxicity of GO. The results indicated that cytotoxicity and genotoxicity of GO to HLF cells were concentration dependent, and the genotoxicity induced by GO was more severe than the cytotoxicity to HLF cells. Oxidative stress mediated by GO might explain the reason of its toxic effect. Furthermore, the electronic charge on the surface of GO would play a very important role in the toxicity of GO to HLF cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322331900013 |
| 公开日期 | 2014-11-27 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1540]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_朱毅敏团队 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 |
| 推荐引用方式 GB/T 7714 | Wang, AX,Pu, KF,Dong, B,et al. Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells[J]. JOURNAL OF APPLIED TOXICOLOGY,2013,33(10):1156-1164. |
| APA | Wang, AX.,Pu, KF.,Dong, B.,Liu, Y.,Zhang, LM.,...&Zhu, YM.(2013).Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells.JOURNAL OF APPLIED TOXICOLOGY,33(10),1156-1164. |
| MLA | Wang, AX,et al."Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells".JOURNAL OF APPLIED TOXICOLOGY 33.10(2013):1156-1164. |
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