Functionalization of upconverted luminescent NaYF4: Yb/Er nanocrystals by folic acid-chitosan conjugates for targeted lung cancer cell imaging
文献类型：期刊论文
| 作者 | Wang, X (王新) ; Yang, H (杨辉); Wang, X (王新); Zhu, YM (朱毅敏)
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| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
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| 出版日期 | 2011 |
| 卷号 | 21期号:21页码:7661-7667 |
| 通讯作者 | Wang, X (王新) |
| 英文摘要 | We demonstrate a robust approach to functionalize the upconverted luminescent NaYF4:Yb/Er nanocrystals with folic acid (FA)-chitosan conjugates for specific targeting and imaging of lung cancer cells. In this approach, the amine groups of FA-chitosan conjugates covalently reacted with the carboxyl groups located on the surface of dimercaptosuccinic acid (DMSA)-modified NaYF4 : Yb/Er nanoparticles. The produced FA-chitosan-coated NaYF4 : Yb/Er nanoparticles were characterized by means of transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) and photoluminescence (PL) spectroscopy. Additionally, a cell viability assay showed that those FA-chitosan-coated fluorescence nanocrystals were fully biocompatible. Moreover, confocal fluorescence images illustrated that the functionalized-NaYF4 : Yb/Er nanoparticles with FA-chitosan conjugates were specific in targeting lung cancer cell lines (H460) rather than human lung fibroblast (HLF) cells. Consequently, the surface chemistry and functional design of the upconverted luminescence nanocrystals using biocompatible FA-chitosan conjugates might provide a powerful nanoplatform for the detection and molecular diagnosis of lung cancer. |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290670000020 |
| 公开日期 | 2012-08-22 |
| 源URL | [http://58.210.77.100/handle/332007/572]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_朱毅敏团队 |
| 通讯作者 | Wang, X (王新); Wang, X (王新) |
| 推荐引用方式 GB/T 7714 | Wang, X ,Yang, H ,Wang, X ,et al. Functionalization of upconverted luminescent NaYF4: Yb/Er nanocrystals by folic acid-chitosan conjugates for targeted lung cancer cell imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(21):7661-7667. |
| APA | Wang, X ,Yang, H ,Wang, X ,&Zhu, YM .(2011).Functionalization of upconverted luminescent NaYF4: Yb/Er nanocrystals by folic acid-chitosan conjugates for targeted lung cancer cell imaging.JOURNAL OF MATERIALS CHEMISTRY,21(21),7661-7667. |
| MLA | Wang, X ,et al."Functionalization of upconverted luminescent NaYF4: Yb/Er nanocrystals by folic acid-chitosan conjugates for targeted lung cancer cell imaging".JOURNAL OF MATERIALS CHEMISTRY 21.21(2011):7661-7667. |
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