Peptide-Fluorescent Bacteria Complex as Luminescent Reagents for Cancer Diagnosis
文献类型：期刊论文
| 作者 | Zhu, YM(朱毅敏)
|
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-01-18 |
| 卷号 | 8期号:1 |
| 通讯作者 | Zhu, YM(朱毅敏) |
| 英文摘要 | Currently in clinic, people use hematoxylin and eosin stain (H&E stain) and immunohistochemistry methods to identify the generation and genre of cancers for human pathological samples. Since these methods are inaccurate and time consuming, developing a rapid and accurate method to detect cancer is urgently demanded. In our study, binding peptides for lung cancer cell line A549 were identified using bacteria surface display method. With those binding peptides for A549 cells on the surface, the fluorescent bacteria (Escherichia coli with stably expressed green fluorescent protein) were served as specific detecting reagents for the diagnosis of cancers. The binding activity of peptide-fluorescent bacteria complex was confirmed by detached cancer cells, attached cancer cells and mice tumor xenograft samples. A unique fixation method was developed for peptide-bacteria complex in order to make this complex more feasible for the clinic use. This peptide-fluorescent bacteria complex has great potential to become a new diagnostic tool for clinical application. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313872800056 |
| 公开日期 | 2014-01-20 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1518]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_朱毅敏团队 |
| 通讯作者 | Zhu, YM(朱毅敏) |
| 推荐引用方式 GB/T 7714 | Zhu, YM. Peptide-Fluorescent Bacteria Complex as Luminescent Reagents for Cancer Diagnosis[J]. PLOS ONE,2013,8(1). |
| APA | Zhu, YM.(2013).Peptide-Fluorescent Bacteria Complex as Luminescent Reagents for Cancer Diagnosis.PLOS ONE,8(1). |
| MLA | Zhu, YM."Peptide-Fluorescent Bacteria Complex as Luminescent Reagents for Cancer Diagnosis".PLOS ONE 8.1(2013). |
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