In vitro and in vivo evaluation of chitosan microspheres with different deacetylation degree as potential embolic agent
文献类型：期刊论文
| 作者 | Zhou, X (周旋) ; Kong, M (Kong, Ming) ; Cheng, XJ (Cheng, Xiao Jie) ; Feng, C (Feng, Chao) ; Li, J (Li, Jing) ; Li, JJ (Li, Jing Jing) ; Chen, XG (Chen, Xi Guang) |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2014 |
| 卷号 | 113期号:0页码:304-313 |
| 关键词 | Chitosan Microspheres Transcatheter arterial embolization Embolic agent Chemoembilization |
| 通讯作者 | Chen, XG (Chen, Xi Guang) |
| 英文摘要 | To evaluate the potential of N-acetylated chitosan microspheres used as a chemoembolic agent in vivo and in vitro. Calibrated spherical chitosan microspheres (CMs) were prepared via Water-in-Oil emulsification method and CMs were acetylated (ACMs). The swelling rate of CMs was greatly affected by pH than that of ACMs and both of them affected by temperature. Microspheres with excellent thermal stability demonstrated controllable degradation in lysozyme solution. Doxorubicin was released from microspheres in vitro and exhibited excellent control release profile. ACMs caused hemolysis less than CMs (<5% of the time). Co-culture with mouse embryo fibroblasts revealed that microspheres have noncytotoxic nature. Microspheres planted in a rat gluteal muscle demonstrated that it were biodegradable and biocompatible. ACMs were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular occlusion after 15 days. Acetylated chitosan microspheres could be used as potential biocompatible and biodegradable embolic agents. (C) 2014 Published by Elsevier Ltd. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-02-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1841]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_朱毅敏团队 |
| 推荐引用方式 GB/T 7714 | Zhou, X ,Kong, M ,Cheng, XJ ,et al. In vitro and in vivo evaluation of chitosan microspheres with different deacetylation degree as potential embolic agent[J]. CARBOHYDRATE POLYMERS,2014,113(0):304-313. |
| APA | Zhou, X .,Kong, M .,Cheng, XJ .,Feng, C .,Li, J .,...&Chen, XG .(2014).In vitro and in vivo evaluation of chitosan microspheres with different deacetylation degree as potential embolic agent.CARBOHYDRATE POLYMERS,113(0),304-313. |
| MLA | Zhou, X ,et al."In vitro and in vivo evaluation of chitosan microspheres with different deacetylation degree as potential embolic agent".CARBOHYDRATE POLYMERS 113.0(2014):304-313. |
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