Investigation of acetylated chitosan microspheres as potential chemoembolic agents
文献类型：期刊论文
| 作者 | Zhou, Xuan（周旋） ; Kong, Ming ; Cheng, Xiaojie ; Li, Jingjing ; Li, Jing ; Chen, Xiguang |
| 刊名 | Colloids and surfaces. B, Biointerfaces
 |
| 出版日期 | 2014 |
| 卷号 | 123期号:0页码:387-94 |
| 关键词 | Chitosan Cytotoxicity Hemocompatibility Hemolysis Microspheres Thrombogenicity |
| 通讯作者 | Zhou, Xuan（周旋） |
| 英文摘要 |
The aim was to investigate the potential of chitosan microspheres (CMs) with
different acetylation using as a chemoembolic agent. Chitosan microspheres (CMs)
were prepared via water-in-oil (W/O) emulsification cross-linking method, and
acetylated chitosan microspheres (ACMs) were obtained by acetylation of CMs. Next,
we characterized the morphology, size, composition and degrees of deacetylation
using scanning electron microscopy (TEM), dynamic laser light scattering (DLS), and
Fourier transform infrared spectrometer (FTIR). All microspheres had smooth surfaces
and good mechanical flexibility, and all could pass through a 5F catheter. The
swelling rate (SR) of CMs decreased significantly with the increase of pH (4.0-10.0)
but ACMs did not change under the same conditions. Protein absorption assays
suggested that albumin was more greatly adsorbed on CMs than on ACMs. Furthermore,
CMs caused more blood clots than ACMs. ACMs caused hemolysis less than CMs (<5% of
the time). Data indicated that ACMs had more hemocompatibility. Cytotoxicity tests
indicated that ACMs initially had less cell attached proliferation but increased
with incubation. In contrast, the relative growth rate of mouse embryo fibroblasts
(MEFs) on CMs decreased gradually. The results suggested that ACMs could stimulate
the growth of MEFs, and CMs were not cytotoxic to MEFs. Thus, ACMs were more
biocompatible with greater potential to be used as chemoembolic material. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-02-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1855]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_朱毅敏团队 |
| 推荐引用方式 GB/T 7714 | Zhou, Xuan,Kong, Ming,Cheng, Xiaojie,et al. Investigation of acetylated chitosan microspheres as potential chemoembolic agents[J]. Colloids and surfaces. B, Biointerfaces,2014,123(0):387-94. |
| APA | Zhou, Xuan,Kong, Ming,Cheng, Xiaojie,Li, Jingjing,Li, Jing,&Chen, Xiguang.(2014).Investigation of acetylated chitosan microspheres as potential chemoembolic agents.Colloids and surfaces. B, Biointerfaces,123(0),387-94. |
| MLA | Zhou, Xuan,et al."Investigation of acetylated chitosan microspheres as potential chemoembolic agents".Colloids and surfaces. B, Biointerfaces 123.0(2014):387-94. |
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