Multifunctional fluorescent magnetic nanoparticles for lung cancer stem cells research
文献类型：期刊论文
| 作者 | Zhou, X(周旋); Chen, LS(陈丽莎); Wang, AX(王安欣); Ma, YF(马宇飞); Zhang, HL(张海禄); Zhu, YM(朱毅敏)
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| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
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| 出版日期 | 2015 |
| 卷号 | 134页码:9 |
| 关键词 | Multifunctional magnetic nanoparticles Cancer stem cell Tumor targeting in vivo Fluorescent imaging Magnetic resonance imaging |
| 通讯作者 | Zhu, YM (朱毅敏) |
| 英文摘要 | In this paper, a multifunctional peptide-fluorescent-magnetic nanocomposites (Fe3O4@PEI@Cy5.5@PEG@HCBP-1 NPs) was synthesized via a layer-by-layer approach for potential application to cancer diagnoses. The multifunctional nanocomposites have great dispersibility and homogeneous particle sizes in aqueous solution. Meanwhile, it has perfect hemocompatibility and satisfying cytocompatibility in a relatively high concentration. Data from in vitro cytotoxicity assay indicated that the nanocomposites could recognize the lung cancer stem cells (CSCs) specifically and enrich the HCBP-1 positive CSCs from H460 tumor xenografts effectively. Additionally, the results of in vivo live fluorescent imaging and magnetic resonance imaging (MRI) showed that the nanocomposites could identify lung CSCs in tumor xenografts. These results suggested that the nanocomposites could be used as a potential cancer diagnostic agent through modifying diverse fluorescence dyes and targeting ligands on its surface. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/3301]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_朱毅敏团队 |
| 推荐引用方式 GB/T 7714 | Zhou, X,Chen, LS,Wang, AX,et al. Multifunctional fluorescent magnetic nanoparticles for lung cancer stem cells research[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2015,134:9. |
| APA | Zhou, X,Chen, LS,Wang, AX,Ma, YF,Zhang, HL,&Zhu, YM.(2015).Multifunctional fluorescent magnetic nanoparticles for lung cancer stem cells research.COLLOIDS AND SURFACES B-BIOINTERFACES,134,9. |
| MLA | Zhou, X,et al."Multifunctional fluorescent magnetic nanoparticles for lung cancer stem cells research".COLLOIDS AND SURFACES B-BIOINTERFACES 134(2015):9. |
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