Research on biomolecule-gate AlGaN/GaN high-electron-mobility transistor biosensors
文献类型：期刊论文
| 作者 | Wu, DM (吴东岷) ; Li, JD (李加东)
|
| 刊名 | ACTA PHYSICA SINICA
 |
| 出版日期 | 2014 |
| 卷号 | 63期号:7 |
| 关键词 | two-dimensional electron gas high electron mobility transistor biosensor prostate specific antigen |
| 通讯作者 | Li, JD (李加东) |
| 英文摘要 | In order to enhance the performance of AlGaN/GaN high electron mobility transistor (HEMT) biosensor, millimeter grade AlGaN/GaN HEMT structure have been designed and successfully fabricated. Factors influencing the capability of the AlGaN/GaN HEMT biosensor are analyzed. UV/ozone is used to oxidize GaN surface and then 3-aminopropyl trimethoxysilane (APTES) self-assembled monolayer can be bound to the sensing region. This serves as a binding layer in the attachment of prostate specific antibody (anti-PSA) for prostate specific antigen detection. The millimeter grade biomolecule-gated GaN/AlGaN HEMT sensor shows a quick response when the target prostate specific antigen in a buffer solution is added to the antibody-immobilized sensing area. The detection capability of this biomolecule-gate sensor estimated to be below 0.1pg/ml level using a 2 x 1 : 5 mm 2 sensing area, which is the best result of GaN/AlGaN HEMT biosensor for PSA detection till now. The electrical result of the biomolecule-gated GaN/AlGaN HEMT biosensor suggests that this biosensor might be a useful tool for the prostate cancer screening. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336090000004 |
| 公开日期 | 2015-02-03 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/1812]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米研究国际实验室_吴东岷团队 |
| 通讯作者 | Li, JD (李加东) |
| 推荐引用方式 GB/T 7714 | Wu, DM ,Li, JD . Research on biomolecule-gate AlGaN/GaN high-electron-mobility transistor biosensors[J]. ACTA PHYSICA SINICA,2014,63(7). |
| APA | Wu, DM ,&Li, JD .(2014).Research on biomolecule-gate AlGaN/GaN high-electron-mobility transistor biosensors.ACTA PHYSICA SINICA,63(7). |
| MLA | Wu, DM ,et al."Research on biomolecule-gate AlGaN/GaN high-electron-mobility transistor biosensors".ACTA PHYSICA SINICA 63.7(2014). |
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